COMPARISON OF CHORION VILLUS SAMPLING AND AMNIOCENTESIS

绒毛活检--一种获取产前胎儿细胞的技术 目前正在积极调查中。基因检测 羊膜穿刺术的缺陷对医学做出了重大贡献 遗传学，但绒毛活检可能提供产前检查的途径 对更多未发现中期妊娠的妇女的诊断 可以接受的程序。使用率将迅速增加 绒毛膜活检的安全性和安全性的研究 迫切需要这一程序的准确性。要实现这一点，a 使用相同协议的多个中心的协作工作是 必填项。 提出了一个模型协议，用于患者登记、遗传咨询、 妊娠约会、宫颈培养、手术操作、样本 处理、数据收集和程序评估。这将允许 (1)绒毛活检准确性的建立 基因异常胚胎/胎儿的鉴定，以及(2) 自然流产、低出生体重、早产等并发症 胎盘早剥、Rh同种免疫、胎儿畸形和新生儿 与绒毛取样相关的发育迟缓。

Chorionic villus biopsy, a technique for obtaining fetal cells for prenatal diagnosis, is now actively being investigated. Detection of genetic defects by amniocentesis has made significant contributions to medical genetics, but chorionic villus biopsy may offer access to prenatal diagnosis to a much larger group of women who do not find second trimester procedures acceptable. There will be a rapid increase in the utilization of chorionic villus biopsy and, therefore, a study of the safety and accuracy of this procedure is urgently needed. To accomplish this a collaborative effort of a number of centers utilizing the same protocol is required. A model protocol is presented for patient enrollment, genetic counseling, pregnancy dating, cervical culture, procedure performance, sample processing, data collection, and procedure assessment. This will allow establishment of (1) the accuracy of chorionic villus biopsy in identification of genetically abnormal embryos/fetuses, and (2) the rate of such complications as spontaneous abortions, low birth weight, prematurity placental abruption, Rh isoimmunization, fetal malformations, and neonatal developmental delay associated with chorionic villus sampling.