PULMONARY COMPLICATIONS OF HIV INFECTION

这是来自多中心肺艾滋病中心的六份提交材料之一。 并发症研究（PACS）项目。 我们的主要目标是继续 研究提供了关于肺部疾病的频率和类型的数据， 发生在艾滋病毒感染者，并描述过程， 这些疾病的后果。 将特别注意 确定人口统计学亚组中的并发症模式， 没有被广泛研究，如妇女和黑人， 确定艾滋病毒传播群体之间的差异。 独特的队列 这也将为PACS提供一个机会， 对特定并发症的新见解，如气道疾病和 结核病，允许测试新的方法来诊断 结核感染和肺部并发症的预测， 允许更好地定义早期肺部事件对 艾滋病毒感染的后期阶段及其并发症。 该信息 对于临床策略和合理政策的制定至关重要 决定如何分配资源以协助艾滋病毒感染者。 该研究将继续使用6个临床中心，包括UMDNJ-New 泽西医学院和数据协调中心。 这项研究将 保持其队列及其前瞻性，纵向设计， 评估按HIV（辅助性T细胞）淋巴细胞分组的参与者。 标准化的临床和实验室研究，在以下方面具有证明价值： 检测肺部并发症，系统地应用于检测 HIV相关并发症。 这些测试的结果是相互关联的 人口统计学和免疫学数据。 其他研究使用我们的 血清库会给我们提供一个机会 与识别特定并发症相关的观察结果， 肺结核。 研究所有组成部分的数据将从 临床中心到协调中心，协调中心将监测 临床中心的绩效，并提供质量控制， 确保数据质量的一致性。 协调中心还将 除了内部提供的统计专门知识外， 临床中心，以促进研究数据的分析。

This submission is one of six from the multicenter Pulmonary AIDS Complications Study (PACS) project. Our primary aim is to continue a study providing data on the frequency and types of lung diseases that occur in persons with HIV infection and to describe the course and outcome of these disorders. Particular attention will be given to identifying patterns of complications among demographic subgroups that have not been extensively studied such as women and Blacks, and to defining differences between HIV transmission groups. The unique cohort that has been established by PACS will also provide an opportunity for new insights into particular complications such as airway disease and tuberculosis, allow the testing of novel approaches to the diagnosis of tuberculous infection and the prediction of pulmonary complications, and allow a better definition of the impact of early pulmonary events on the later stages of HIV infection and its complications. This information is essential to the development of clinical strategies and sound policy decisions for the allocation of resources to assist HIV infected persons. The study will continue to use 6 clinical centers, including UMDNJ-New Jersey Medical School and a data coordinating center. The study will maintain its cohort and its prospective, longitudinal design for the evaluation of participants grouped by HIV (T-helper) lymphocytes. Standardized clinical and laboratory studies, of proven value in detecting pulmonary complications, are systematically applied to detect HIV-associated complications. The results of these tests are correlated with demographic and immunologic data. Additional studies using our serum bank will provide us an opportunity to extend preliminary observations related to the identification of specific complications such as tuberculosis. Data from all components of the study will be transmitted from the Clinical Centers to the Coordinating Center which will monitor performance of the Clinical Centers as well as provide quality control to assure uniformity of data quality. The Coordinating Center will also provide statistical expertise, in addition to that available from within the Clinical Centers, to facilitate the analysis of study data.