NHLBI GROWTH AND HEALTH STUDY EXTENSION

国家心肺和血液辛辛那提临床中心 研究所的生长和健康研究（NGHS-I，HC 55025），结合 它的合作中心，建议扩展到目前的研究， 这组人从9岁到10岁被跟踪了5年， 13岁和14岁可以在整个青春期进行跟踪。 NGHS倡议的目标是描述和解释a） 黑人女性在青春期的肥胖发生率更高，B）其 与主要心血管疾病（CVD）风险因素的相关性。 的 因此，辛辛那提中心建议在女孩队列中测量 再过三年：1）先前因素（例如，饮食，锻炼， 心理社会因素）; 2）身体形态（如身高、体重、皮褶，以及 围，和成熟状态）;和3）CVD的危险因素， 体质（如血压和血脂）。 家长和监护人 女孩们也将接受评估。 建议的扩展描述于 在合作补助金申请的细节。 辛辛那提中心在NGHS-I中进行了一项以学校为基础的研究： 受试者来自公立四年级和五年级的班级， 以及辛辛那提和周边汉密尔顿县的教区学校 从种族、地理和社会经济上选择 该地区的代表。 辛辛那提中心招收了867名学生， 白色430，黑色437。 在NGHS-I结束时，女孩们将在年级 第8和第9条。 在扩展阶段（NGHS-II），受试者将在9-12年级。 的 辛辛那提中心建议继续进行以学校为基础的研究，尽管一些 受试者必须在儿童医院或其家中就诊， 各种原因（例如，移动到该地区以外，但在100英里内 辛辛那提，转移到一个学校，将不合作， （这是迄今为止没有发生的），或辍学。 的 辛辛那提中心将继续使用基本相同的工作人员， 技术，和NGHS-I中使用的激励措施。 使用这些方法， 辛辛那提中心与其合作伙伴一样， 队列中的优秀留存率：（89%）仍在研究中， 第四年年底。

The Cincinnati Clinical Center of the National Heart Lung and Blood Institute's Growth and Health Study (NGHS-I, HC 55025), in conjunction with its collaborating centers, proposes an extension to the current study so that the cohort being followed for five years from ages 9 and 10 years to ages 13 and 14 years can be followed through the entire pubertal period. The goals of the NGHS initiative were to describe and explain a) the greater incidence of obesity in black females during adolescence and b) its association to major cardiovascular disease (CVD) risk factors. The Cincinnati Center, therefore, proposes to measure in the cohort of girls for three more years: 1) antecedent factors (e.g., diet, exercise, and psychosocial factors); 2) body habitus (e.g. height, weight, skinfolds, and circumferences, and maturation status); and 3) CVD risk factors affected by body habitus (e.g. blood pressure and lipids). Parents and guardians of the girls will also be evaluated. The proposed extension is described in detail in the collaborative grant application. The Cincinnati Center has conducted a school-based study in NGHS-I: subjects were enrolled from the fourth and fifth grade classes of public and parochial schools in Cincinnati and surrounding Hamilton County selected from to be racially, geographically, and socioeconomically representative of the area. The Cincinnati Center enrolled 867 students, 430 white and 437 black. At the end of NGHS-I, the girls will be in grades 8 and 9. In the extension (NGHS-II), subjects will be in grades 9-12. The Cincinnati Center proposes to continue a school-based study, though some subjects will have to be seen at Children's Hospital or their home for a variety of reasons (e.g. moving outside the area, but within 100 miles of Cincinnati, transferring to a school which will not cooperate with the study (this has not occurred to date), or dropping out of school.) The Cincinnati Center will continue to use basically the same staff, techniques, and incentives used in NGHS-I. Using these methods, the Cincinnati Center, like its collaborating partners, has achieved an excellent retention rate in the cohort: (89%) were still in the study at the end of Year 4.