DIETARY PATTERNS AND BLOOD PRESSURE

这项建议是协调中心(CC)对RFA关于饮食的回应 模式和血压。文化中心将设在凯撒酒店 常设健康研究中心(CHR)，咨询来自 俄勒冈健康科学大学和食品成分分包合同 弗吉尼亚理工学院的分析。卫生与公众服务部和调查人员 有丰富的临床试验经验，高血压 研究、喂养研究、食物分析以及处理和分析 大型数据库。申请者也有协调工作的经验。 中心，而CHR的结构以最佳方式支持这样的 机构。 我们建议进行一次三人参与的审判，在此之前进行为期4周的磨合。 美国人的饮食。典型的美国人的饮食将继续作为 在研究的干预阶段控制饮食。两个人 比较涉及高矿物质(钾、镁、钙)和低脂肪-高纤维 节食。我们还建议将不容易腐烂的食物放在中央 厨房，冷冻，并运往临床中心，以最大限度地提高 节食，最大限度地减少质量控制问题。最后，我们提出了一种 降低血压变化的机制利用 受试者的日常访问情况。拟议的设计具有相当大的 比模型检测血压变化的能力更大 在RFA中建议。 申请者的专业知识和经验的结合使 CHR及其附属科学家是一个理想的群体 这场审判的协调中心。

This proposal is a Coordinating Center (CC) response to the RFA on Dietary Patterns and Blood Pressure. The CC will be located at the Kaiser Permanente Center for Health Research (CHR), with consultation from the Oregon Health Sciences University and a subcontract for food composition analyses to Virginia Polytechnic Institute. The CHR and the investigators have extensive experience in the conduct of clinical trials, hypertension research, feeding studies, food analysis, and the handling and analysis of large databases. The applicants also have experience as a coordinating center, and the CHR is structured to optimally support such an institution. We propose a three-armed trial, preceded by a 4-week run-in, "typical American" diet. The "typical American" diet would be continued as the control diet during the intervention phase of the study. The two comparisons would involve high mineral (K, Mg, Ca) and low fat-high fiber diets. We also propose that non-perishable foods be prepared in a central kitchen, frozen, and shipped to clinical centers to maximize uniformity of diets and minimize quality control problems. Finally, we propose a mechanism for reducing variance in blood pressure by taking advantage of the daily visits of trial subjects. The proposed design has considerably greater power for detecting changes in blood pressure than does the model suggested in the RFA. The combination of expertise and experience of the applicants makes the CHR and its affiliated scientists an ideal group for serving as coordinating center for this trial.