BIOLOGICAL MARKERS IN TREATMENT OF PROSTATE CANCER

这项建议的目的是继续提供研究和 实验室核心支持国家临床试验合作组织 癌症研究所的国家前列腺癌项目。 的目的 质量控制，各参与中心必须 具有统一的生物标志物，与监测 前列腺癌的治疗和管理，在各种治疗方案。 可以有效地进行客观的临床病理学评价 在一个合作的小组中，仅仅从一套标准的测试和数据中。 的 评价将根据在 中央统计局的小组，并从多个实验室测试， 如本提案所述， 当地或常规参与医院。 血清前列腺特异 抗原、前列腺酸性磷酸酶、骨同工酶和肝同工酶 将测量碱性磷酸酶。 任何新的生物标志物或检测 这将表明改善和/或增加的临床价值， 监测前列腺癌的治疗反应，可以添加到 测试小组，因为他们变得可用。 计算机辅助统计 技术，例如考克斯模型和逻辑模型等，将被 用于系统和客观的临床实验室分析。 此外，建立并清点了前列腺增生症患者血清库， 癌症将得到精心维持并进一步扩大。 这个血清库 是一种国家资源。 这项更新建议的目的是 继续发挥中心实验室的核心职能， 主要组成部分，并在持续成功中发挥了重要作用 前列腺癌的主要合作临床试验， 由国家癌症研究所赞助。

The objective of this proposal is to continue to provide research and laboratory core support to the Cooperative Clinical Trials of the National Cancer Institute's National Prostatic Cancer Project. For purpose of quality control, it is imperative for the various participating centers to have uniform biological markers, relevant to monitoring the efficacy of prostate cancer treatment and management, in various treatment protocols. An objective clinical pathological evaluation can be performed effectively in a cooperative group only from a standard set of tests and data. The evaluation will be carried out from clinical information compiled at the Central Statistics Office of the group, and from multiple laboratory tests, as provided by this proposal, that are not readily available in participating hospitals locally or routinely. Serum prostate-specific antigen, prostatic acid phosphatase, bone isoenzyme and liver isoenzyme of alkaline phosphatase will be measured. Any new biomarkers or assay procedures, which will indicate improved and/or additive clinical value in monitoring the treatment response of prostate cancer, can be added to the panel of tests as they become available. Computer-assisted statistical techniques, e.g. the Cox model and logistic model, among others, will be used for systematic and objective clinical-laboratory analysis. Additionally, establishment and inventory of a serum bank of prostate cancer will be carefully maintained and further expanded. This serum bank represents a national resource. The purpose of this renewal proposal is to continue the core function of this central laboratory, which has been a major component and has played as essential role in the continued success of the major cooperative clinical trial on prostate cancer under the auspices of the National Cancer Institute.