CONTROL OF CELL PROLIFERATION IN CACHECTIC ELDERLY WITH & WITHOUT DECUBITUS ULCER

该项目旨在验证以下假设： 恶病质，以低瘦体重、贫血、低白蛋白血症为特征 和/或低胆固醇血症损害细胞生长和代谢， 低水平的细胞生长因子，高水平的抑制因子， 因子或低循环脂蛋白水平。 在体外系统中， 成纤维细胞增殖，通过3 H-胸苷掺入 DNA，正被用于分析来自老年受试者的血浆和血清， 生长刺激或抑制水平。 该项目可能会给 深入了解导致体重减轻和促进 老年人发生褥疮性皮肤溃疡。

This project is designed to test the hypothesis that patients with cachexia, characterized by low lean body mass, anemia, hypoalbuminemia and/or hypocholesterolemia have impaired cell growth and metabolism because of low levels of a cellular growth factor, elevated levels of an inhibitory factor or low circulating lipoprotein levels. In in vitro systems using fibroblast cell proliferation, measured by 3H-thymidine incorporation into DNA, is being used to assay plasma and sera from elderly subjects for growth stimulatory or inhibitory levels. This project may give significant insight into the mechanisms causing weight loss and promoting the occurrence of decubitus skin ulcers in the elderly.