THE PATHOPHYSIOLOGY OF THE ALCOHOL WITHDRAWAL SYNDROME

在这个项目中，我们探讨了两个重要的临床病理生理学 在慢性酒精戒断过程中经常观察到的问题： (1)睡眠-觉醒周期紊乱，（2）对 感染 24小时体温测量，运动 活动，动态心电图，尿儿茶酚胺排泄将是 在急性戒断的酗酒者身上进行的实验。 虽然 最初，这项研究旨在获得这些测量期间， 停药后的前72小时，我们病房最近的研究表明， 这一时间框架应该改变。 因此，我们正在评估生物 停药后第一、三、八天的24小时节律。 还有， 每半小时采集一次血浆皮质醇， 褪黑激素将每小时测定一次（而不是每三小时测定一次， 在此期间，最初提出。 由于限制在 血样总体积，卧位-站立位去甲肾上腺素测定 将无法获得。 酒精中毒患者与年龄和性别匹配的对照组 将评价一般免疫活性，以确定 长期酗酒和戒酒对免疫系统的影响。 将定期对患者进行评价，以研究 不同的戒酒持续时间对选定的参数 免疫活性

In this project, we explore the pathophysiology of two important clinical problems frequently observed in the chronic alcoholic during withdrawal: (1) disturbed sleep-wake cycle, and (2) increased susceptibility to infection. Twenty-four hour measurements of body temperature, motor activity, ambulatory EGG, and urinary catecholamine excretion will be performed on acutely withdrawing alcoholics during withdrawal. Although originally this study was designed to obtain these measurements during the first 72 hours of withdrawal, recent research from our ward indicated that this time frame should be altered. We are, therefore, evaluating biologic rhythms in 24 hours on days one, three, and eight of withdrawal. Also, plasma cortisol will be obtained every half-hour and plasma ACTH and melatonin will be determined every hour (rather than every three hours as originally proposed) during these periods. Because of limitation on the total volume of blood samples, lying-standing norepinephrine determinations will not be obtained. Alcoholic patients and age- and sex matched controls will be evaluated for general immunocompetence to determine the effects of long-term alcohol abuse and withdrawal from alcohol on the immune system. Patients will be evaluated at regular intervals to investigate effects of varying durations of abstinence from alcohol on selected parameters of immunocompetence.