MULTICENTER NETWORK OF NEONATAL INTENSIVE CARE UNITS

本意见书的主要目的是重新申请指定 作为被选中参加新生儿网络的中心之一 重症监护室。迈阿密大学新生儿科 拥有充足的临床患者群体，杰出的临床， 实验室和研究设施，以及称职、敬业的人员。 在个人调查工作中有丰富的研究经验。 以及大型协作多中心临床试验。这个 迈阿密大学积极参与了最初的5年周期 NICU网络的成员。尽管在Low的数量上一直排名第三 出生体重新生儿入院人数，他们一直位居 被随机纳入第一次重大网络试验的婴儿总数 预防性静脉注射免疫球蛋白。他们有 在其他大型多中心取得成功的丰富经验 临床试验，如产前应用糖皮质激素(NHLBI)， 高频呼吸机(NHLBI.和婴幼儿的健康与发展 项目(罗伯特·伍德·约翰逊)。他们致力于实现根本目标 网络的安全性和有效性，即评估新的 使用大型多点随机临床试验的治疗方式， 而不是有限的个人经验或偏好。这所大学 迈阿密有大量的母婴新生儿人口 每年大约有14,000例活产分娩。此外，它还提供 作为一个地区的第三区域转诊中心，该地区包括 40,000名新生儿，并接受中环和县外的转介 南美洲和加勒比海地区。新生儿特别护理中心 经常进行超过120-130%的人口普查。现在的高风险团队 包括200多名全职工作人员，他们的工作专门用于 新生儿和他们的家人。新生儿科教员的范围很广。 在肺脏和发育医学领域的专业知识，物质 虐待、感染性和中枢神经系统紊乱。长期的 多学科发展评估和干预计划是 由拟议的P.I.迈阿密大学指导，并承诺 相关的临床研究，其现有的人口，设施和 人员，以及其在过去一年中成功合作的可靠记录 十年，有强烈的愿望继续在新生儿ICU网络和 有助于有效解决复杂的诊断和治疗问题 新生儿的问题。

The primary objective of this submission is to re-apply for designation as one of the centers selected to participate in the Network of Neonatal Intensive Care Units. The University of Miami's Division of Neonatology possesses an adequate clinical patient population, outstanding clinical, laboratory and research facilities, and competent, dedicated personnel. It has an extensive research experience in individual investigative work as well as in large collaborative multicenter clinical trials. The University of Miami has actively participated in the initial 5 year cycle of the NICU Network. Although consistently ranking third in number of low birth weight neonatal admissions, they have consistently ranked first in total numbers of infants randomized into the first major network trial on prophylactic intravenous immunoglobulin administration. They have extensive previous experience in other large multi-center successful clinical trials, such as prenatal glucocorticoid administration (NHLBI), high frequency ventilation (NHLBI. and the infant health and development program (Robert Wood Johnson). They are dedicated to the underlying goal of the Network which is to evaluate both the safety and efficacy of new therapeutic modalities using large multi-site randomized clinical trials, as opposed to limited personal experience or preference. The University of Miami has access to a large maternal-fetal-neonatal population approximating 14,000 live-born deliveries per year. In addition, it serves as the tertiary regional referral center for an area encompassing over 40,000 births and it receives out of county referrals from Central and South America and the Caribbean. The Neonatal Special Care Center routinely runs a census exceeding 120-130%. The high-risk team now includes over 200 full-time personnel whose work is exclusively devoted to neonates and their families. The neonatology faculty possess a wide range of expertise in areas of pulmonary and developmental medicine, substance abuse and infectious and central nervous system disorders. A longterm multi-disciplinary developmental evaluation and intervention program is directed by the proposed P.I. The University of Miami, with its commitment to relevant clinical research, its existing population, facilities and personnel, and its proven record of successful collaboration over the last decade, has a strong desire to continue in the Neonatal ICU Network and to contribute to effectively addressing the complex diagnostic and therapeutic problems of the newborn.