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THE STRUCTURE DETERMINATION OF AIDS GLYCOPROTEIN FRAGMENTS

THE STRUCTURE DETERMINATION OF AIDS GLYCOPROTEIN FRAGMENTS
艾滋病糖蛋白片段的结构测定
批准号：
3896413
负责人：
B R BROOKS
金额：
$0.0万
依托单位：
CENTER FOR INFORMATION TECHNOLOGY
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/3896413
关键词：
AIDS AIDS therapy X ray crystallography antiAIDS agent antiviral agents chemical models computer assisted sequence analysis computer graphics /printing computer simulation drug design /synthesis /production glycoproteins human immunodeficiency virus 1 nuclear magnetic resonance spectroscopy protein sequence protein structure viral vaccines virus antigen virus envelope

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中文摘要
翻译
我们现在正积极参与校内的努力， 艾滋病的抗病毒剂。我们最初发表的工作集中在 所选部分的三维结构测定 表面糖蛋白GPI 20和GP 41。迄今所做的工作表明， HIV-1 gp 4l两亲性片段的可能结构 包膜蛋白，并可能对目前的疫苗产生影响 发展努力。我们的研究结果表明， gp 120-gp 41复合物的致细胞病变作用。我们还在等待 NMR或X射线晶体学的实验数据来支持 为这个潜在的靶点设计抗病毒剂的进一步努力 地区
英文摘要
We are now actively involved with the intramural effort to develop an antiviral agent for AIDS. Our initial published work has focused on the threedimensional structure determination of selected portions of the surface glycoproteins GPI20 and GP41. The work performed to date proposes possible structures for the amphipathic segments of the HIV-1 gp4l envelope protein, and may have implications for current vaccine development efforts. Our results suggest a possible mechanism for the cytopathic effects of the gpl2O-gp4l complex. We still await further experimental data from NMR or from X-ray crystallography to support further efforts in designing an antiviral agent for this potential target region.
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