Rosalind Franklin Institute - Next Generation Chemistry

生命科学行业是英国经济的重要组成部分：它拥有超过22万名员工，对GDP和英国贸易平衡做出了重大贡献，对开发前沿治疗方法至关重要。它以英国在健康和生命科学方面世界领先的研究基地为基础。反过来，工程和物理科学（EPS）研究的进步使许多关键的研究突破成为可能，这些研究提供了越来越复杂的仪器和方法，以支持对活生物体（从微生物到植物、动物和人体）和生物过程（包括疾病病理学和药物作用）的研究。整个生态系统的研发——从基础认识到应用研究再到产品开发——对于实现长期经济增长和农业、食品安全、医疗保健和公共卫生领域的持续进步至关重要。历史上的创新模式往往是线性的，涉及一定程度的意外发现。如果物理科学家、工程师、生命科学家和工业界大规模合作，颠覆性技术和科学突破将会加速。这是罗莎琳德·富兰克林研究所（Rosalind Franklin Institute， RFI）的领域：在哈维尔科学与创新校区有一个中心（Hub），与英国领先的高等教育学院的正式辐条相连，它将整合学术界和工业界的互补专业知识，创建一个国家卓越中心，在物理和生命科学的融合中开发方法。生物样品的多种化学控制和编辑具有深远的潜力，远远超出了物理或生物科学传统模式的现有方法。这将最终补充和迭代地决定富兰克林的其他统一目标的价值，如成像。“编辑-特征-成像”的能力不仅可以为观察（成像）生物学，还可以为控制（编辑/治疗）生物学提供一个巨大的挑战方法，从而在其翻译后状态下理解它作为一种新的医学模式。下一代化学（NGC）的路线图将统一几个子项目，这些子项目将跨越化学控制和生物学理解的范围。NGC主题使用的标题是：构建（合成生物学）->理解（化学生物学）->控制（化学医学）在构建中，我们的目标是自下而上地构建和编辑复杂的生物实体。在《理解》一书中，我们描述了建筑和调制结构与功能之间的关系。在控制中，我们利用这种理解来迭代地调节和纠正功能，主要应用于医学和生物技术。

The Life Sciences sector forms a key part of the UK economy: it employs over 220,000 people, contributes significantly to GDP and UK balance of trade, and is crucial for developing leading-edge treatments. It is underpinned by the UK's world-leading research base in the health and life sciences. Many key research breakthroughs are, in turn, enabled by advances in engineering and physical sciences (EPS) research - which provide ever more sophisticated instrumentation and methods to support the study of living organisms (from microbes to plants, animals and the human body) and biological processes (including both disease pathology and drug action). R&D across all parts of this ecosystem - from fundamental understanding to applied research to product development - is crucial for the delivery of long-term economic growth and continued advances in agriculture, food security, healthcare and public health. Historic models of innovation have often been linear, involving a degree of serendipity. Disruptive technologies and scientific breakthroughs will be accelerated if physical scientists, engineers, life scientists and industry work together, and at scale. This is the domain of the Rosalind Franklin Institute (RFI): with a focal point (Hub) at Harwell Science and Innovation Campus, linked to formal Spokes in leading HE ls across the UK, it will integrate complementary expertise from academia and industry to create a national centre of excellence for methods development at the convergence of the physical and life sciences.The diverse chemical control and editing of biological samples has profound potential well beyond current methods in traditional modes of Physical or Biological Sciences. This will ultimately complement and iteratively determine the value of other unifying goals of the Franklin such as Imaging. The ability to 'edit-characterize-and-image' could provide a grand challenge method for not only observing (imaging) biology but controlling (editing/treating) and hence understanding it in its post-translational state as a new mode of Medicine. The roadmap for Next Generation Chemistry (NGC) will unify several sub-projects that will span this spectrum of chemical control and understanding of biology.The NGC theme uses the rubric of:Construct (Synthetic Biology) -> Understand (Chemical Biology) -> Control (Chemical Medicine)In Construct, we aim to build and edit complex biological entities from the bottom-up.In Understand, we characterize and hence correlate built and modulated structures with function.In Control, we exploit this understanding to iteratively modulate and correct function with application primarily in Medicine and Biotechnology.