Understanding a Mutant that Disregulates Trehalose 6-Phosphate Action in Plants

光合作用中形成的蔗糖是所有植物产品合成的起点，包括那些参与生长和发育的产品，作物收获的器官，以及淀粉、细胞壁、蛋白质和脂肪的合成，这些都是食物、纤维、饲料和燃料的成分。海藻糖6-磷酸(T6P)是一种糖信号，或糖燃料计，与蔗糖生物学密切相关，向细胞传递有关蔗糖有效性的信息。尽管T6P信号系统在植物和作物中具有不可或缺的重要性，但关于调节T6P积累的机制仍有许多悬而未决的问题。这作为一项重大的科学挑战具有重要意义，即植物“血糖”的调节，以及T6P确定总体生长、产量和对非生物和生物胁迫的抗性的基础，以及转化为增加作物产量和作物抗逆性的形式。为了解决植物如何调控T6P积累的根本问题，从而解决所有这些依赖的过程，我们聚集了化学生物学和分子植物科学的研究人员，利用分子遗传学、生化、化学和多重组学中无与伦比的工具，了解特定的海藻糖磷酸合成酶和蛋白激酶的作用及其相互作用，以及与其他蛋白质和配体的相互作用。

Sucrose formed in photosynthesis is the starting point for the synthesis of all plant products including those involved in growth and development, the harvested organs of crops, and the synthesis of starch, cell walls, proteins and lipids, which are the constituents of food, fibre, feed and fuel. Trehalose 6-phosphate (T6P) is a sugar signal, or sugar fuel gauge intimately involved with sucrose biology relaying information to cells about the availably of sucrose. Despite the indispensable importance of the T6P signalling system in plants and crops there are many unanswered questions about the mechanisms involved in regulating the accumulation of T6P. This has important implications as a science grand challenge i.e. the regulation of plant "blood sugar" and the basis of T6P's determination of overall growth, yield and resistance to abiotic and biotic stresses, and translation in the form of increased crop yields and crop resilience. To address the fundamental question of how plants regulate T6P accumulation and hence all these processes on which this depends, we bring together a unique collaboration of researchers in chemical biology and molecular plant science applying tools unrivalled in one consortium of molecular genetic, biochemical, chemical and multi omics to understand the role of specific trehalose phosphate synthases and a protein kinase and their interaction with each other, and with other proteins and ligands.