Understanding a Mutant that Disregulates Trehalose 6-Phosphate Action in Plants

了解破坏植物中海藻糖 6-磷酸作用的突变体

• 批准号: BB/T016329/1
• 负责人: Benjamin Davis
• 金额: $ 101.75万
• 依托单位: Rosalind Franklin Institute
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2020
• 资助国家: 英国
• 起止时间: 2020 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=BB%2FT016329%2F1
• 关键词: Understanding; Mutant; Disregulates; Trehalose; Phosphate

Sucrose formed in photosynthesis is the starting point for the synthesis of all plant products including those involved in growth and development, the harvested organs of crops, and the synthesis of starch, cell walls, proteins and lipids, which are the constituents of food, fibre, feed and fuel. Trehalose 6-phosphate (T6P) is a sugar signal, or sugar fuel gauge intimately involved with sucrose biology relaying information to cells about the availably of sucrose. Despite the indispensable importance of the T6P signalling system in plants and crops there are many unanswered questions about the mechanisms involved in regulating the accumulation of T6P. This has important implications as a science grand challenge i.e. the regulation of plant "blood sugar" and the basis of T6P's determination of overall growth, yield and resistance to abiotic and biotic stresses, and translation in the form of increased crop yields and crop resilience. To address the fundamental question of how plants regulate T6P accumulation and hence all these processes on which this depends, we bring together a unique collaboration of researchers in chemical biology and molecular plant science applying tools unrivalled in one consortium of molecular genetic, biochemical, chemical and multi omics to understand the role of specific trehalose phosphate synthases and a protein kinase and their interaction with each other, and with other proteins and ligands.

在光合作用中形成的蔗糖是合成所有植物产品的起点，包括参与生长和发育的植物产品、收获的作物器官以及淀粉、细胞壁、蛋白质和脂质的合成，这些是食物、纤维、饲料和燃料的成分。海藻糖6-磷酸（T6 P）是一种糖信号，或糖燃料测量仪，与蔗糖生物学密切相关，将有关蔗糖可用性的信息传递给细胞。尽管T6 P信号系统在植物和作物中具有不可或缺的重要性，但关于T6 P积累的调节机制仍有许多未解之谜。这具有重要的意义，作为一个科学的大挑战，即植物“血糖”的调节和T6 P的整体生长，产量和对非生物和生物胁迫的抗性的确定的基础，以及以增加作物产量和作物恢复力的形式的转化。为了解决植物如何调节T6 P积累的基本问题，以及因此所依赖的所有这些过程，我们汇集了化学生物学和分子植物科学研究人员的独特合作，应用分子遗传学，生物化学，化学和多组学联盟中无与伦比的工具，以了解特定海藻糖磷酸脱氢酶和蛋白激酶的作用及其相互作用，以及其他蛋白质和配体。