Process Control and Novel Materials for the Reactive Jet Impingement Process

生物制造技术用于处理天然和合成生物材料，例如细胞、蛋白质和药物，以创造活的组织工程结构。这些结构正被用于研究开发新药和基于细胞的治疗方法，用于广泛的医疗条件。这项研究计划的重点是一种新的3D打印技术，称为反应射流撞击（ReJI），可用于生物制造。与现有技术相比，ReJI技术在一定体积内可以沉积的细胞数量，以及可以打印的材料和形状的范围方面具有一些优势。该研究方案将着重于三件事：(i)改进技术，方法是开发一个过程的计算模型，以支持实验研究并为其提供信息，以及在打印能力方面扩大技术的规模。扩大可使用该技术加工的材料的范围。（iii）将该技术应用于肝癌药物测试和心脏组织工程两个选定应用领域的临床相关组织模型的开发。

Biofabrication techniques are used to process natural and synthetic biomaterials, for example including cells, proteins and drugs, in order to create living, tissue engineered structures. These structures are being used to research the development of new drugs and cell-based therapies for a wide range of medical conditions.This research proposal focuses on a new 3D printing technique called Reactive Jet Impingement (ReJI) which can be used for biofabrication. The ReJI technique has some advantages over existing techniques in terms of the number of cells it can deposit within a certain volume, and in terms of the range of the materials and shapes which it can print on. The research programme will focus on three things: (i) Improving the technology, by developing a computational model of the process to support and inform experimental studies, and through scaling up the technology in terms of print capability.(ii) Extending the range of materials which can be processed using the technology.(iii) Applying the technology to the development of clinically relevant tissue models for two selected application areas in drug testing for liver cancer and cardiac tissue engineering.