GENERAL CLINICAL RESEARCH CENTER

本申请要求继续支持普通临床 芝加哥大学研究中心。 GCRC现已进入第17个年头 在科学研究方面有着杰出的记录 它构成 唯一的住院和门诊研究中心提供给教师。 它 现在有6张病床，并得到充分利用。 本申请要求 增加到8张病床，并开发一个独立的中心， 目前的散床布置。 各种各样的科学调查正在进行中， 内科、外科、儿科和妇产科。 正在进行的科学计划如下。 的影响 输注胰岛素和胰高血糖素对个体肝功能恢复的影响 将研究患有酒精性或坏死后肝功能衰竭的患者。 的 维生素D吸收不良、代谢和血液水平的关系将被 在患有炎症性肠病或类固醇诱导的 骨质减少 肠道疾病的自然史、并发症和益处 将长期研究用于治疗肥胖症的旁路手术。 闭经-乳管综合征的诊断、治疗和自然病程 将被调查。 西咪替丁作为酸反流治疗的作用将是 通过直接测量进入食管的酸反流来定量。 一个 “人工胰腺”将用于评估糖尿病的治疗 酮症酸中毒，脆性糖尿病的管理，并探讨 胰岛素、胰高血糖素和生长激素在代谢适应包括 饥饿和锻炼。 将开发钙输注试验， 胰岛素瘤的诊断 抗体针对膜的患者 胰岛素受体，导致胰岛素糖尿病，将被调查，因为将 可能的治疗方法。 甲状腺疾病的发病率 Graves病和桥本甲状腺炎患者的子女将被 研究了这些患者甲状腺异常的发展过程， 孩子 将进行研究，以确定总的和免费的水平之间的关系。 雄激素与雄激素活性的生物表达。 自然 X射线引起的甲状腺损伤史，包括甲状腺发育 腺瘤和癌，将通过一项严重的随访研究进行评估。 (Text截断-超过容量）

This application requests continued support for operation of a General Clinical Research Center at the University of Chicago. The GCRC is now in its 17th year and has had a distinguished record in scientific investigation. It constitutes the only inpatient and outpatient research Center available to the faculty. It is now operating with 6 beds and is fully utilized. This application requests increase in size to 8 beds, and development of a discrete Center in contrast to the current scatter-bed arrangement. A wide variety of scientific investigations are underway involving members of the Departments of Medicine, Surgery, Pediatrics and Obstetrics and Gynecology. Among the scientific programs underway are the following. The effect of infusion of insulin and glucagon on restoration of liver function in individuals afflicted with alcoholic or postnecrotic liver failure will be studied. The relations of vitamin D malabsorption, metabolism, and blood levels will be studied in individuals who have an inflammatory bowel disease or steroid-induced osteopenia. The natural history, complications, and benefits of intestinal bypass procedures for treatment of obesity will be studied over the long-term. Diagnosis, therapy and natural history of the amenorrhea-galactoria syndrome will be investigated. The role of cimetidine as therapy of acid-reflux will be quantitated by direct measurement of acid-reflux into the esophagus. An "artificial pancreas" will be used to evaluate the treatment of diabetic ketoacidosis, management of brittle diabetics, and to investigate the role of insulin, glucagon and growth hormone in metabolic adaptation to states including starvation and exercise. A calcium infusion test will be developed for diagnosis of insulinomas. Patients with antibodies directed to membrane receptors for insulin, causing insulin diabetes, will be investigated, as will the possible therapy for such conditions. The incidence of thyroid disease in children of patients with Graves' disease and Hashimoto's thyroiditis will be investigated as will the course of development of thyroid abnormalities in these children. Studies will be carried out to correlate the level of total and free androgens with the biologic expression of androgen activity. The natural history of X-ray induced damage to the thyroid, including development of thyroid adenomas and carcinomas, will be evaluated through a follow-up study of sever (Text Truncated - Exceeds Capacity)