ANALYSIS OF LYMPHOPOIESIS IN ANEMIA

拟议研究的目标是在以下方面获得培训和经验 同时进行免疫学研究，同时进行旨在阐明 HA/HA中贫血与淋巴细胞紊乱的相互作用 突变小鼠。对这种动物模型的评估将提供机会 为了一个更广泛的研究环境，可以用来专注于 淋巴生成改变的问题。研究计划将允许开发 新领域的专业知识：(1)分析细胞动力学的标记研究 (2)用特异性抗血清和流式细胞术分析亚群 (3)使用移植研究检查任何关系 红细胞生成和淋巴生成之间的关系以及(4)评价 NK细胞在造血调控中的作用。这些方面的任何一个都可能 为今后的研究提供素材。这些实验将会进行 在常规使用这些技术的实验室中，并在 监督实地有名望的个人。表征 这一小鼠模型的建立可为研究正常小鼠提供资源 淋巴细胞的生成及其与免疫学和免疫学的关系 造血系统。

The goal of the proposed study is to obtain training and experience in immunological research while performing experiments designed to elucidate the interaction of anemia and lymphoid cell perturbations in the ha/ha mutant mouse. Evaluation of this animal model will provide the opportunity for a broadened research environment which can be used to focus on the question of altered lymphopoiesis. Research plan will allow development of expertise in new areas: (1) labeling studies to dissect cellular kinetics (2) use of specific antisera and flow cytometry to analyze subpopulations of cells (3) use of transplantation studies to examine any relationship between erythropoiesis and lymphopoiesis and (4) studies to evaluate the role of NK cells in hemopoietic regulation. Any one of these aspects could offer material for future studies. These experiments will be carried out in laboratories where the techniques are used routinely and under the supervision of well-established individuals in the field. Characterization of this mouse model may provide a resource for studies involving normal lymphopoiesis and the relationship between the immunologic and hematopoietic system.