Consequences of Waveform Composition for Epithelial Integrity and Homogeneous Ventilation during HFOV

高频振荡（HFO）为新生儿提供高达900次/分钟的呼吸。理论上，微小的HFO呼吸减少了呼吸机引起的肺损伤，同时有效地将氧气输送到血液中并清除废气。然而，由于高气体流量，HFO可能会损害大气道。我们将使用数学模型和对早产羔羊的研究来评估如何优化新鲜气体到肺部的分布，同时最大限度地减少任何气道损伤。我们的发现将帮助医生治疗患有肺部疾病的早产儿。

High-frequency oscillation (HFO) delivers up to 900 breaths/minute to newborn babies. In theory, the tiny HFO breaths decrease ventilator induced lung injury whilst efficiently delivering oxygen to and removing waste gas from the blood. However, HFO may damage the large airways due to the high gas flows. We will use mathematical models and studies in preterm lambs to assess how to optimise distribution of fresh gas to the lung while minimising any airway damage. Our findings will help doctors treat preterm babies with lung disease.