TEMPLATED BIOSENSORS IN SEMICONDUCTING SYSTEMS

这项研究的目标之一是开发必要的基础 允许构建生物分子敏感电极的研究。 这种电极，如果它们可以在体内用于监测血糖 水平，可用于调节糖尿病患者的胰岛素流量。 另一类令人感兴趣的生物分子是某些二胺。 一些二胺是在快速分裂的细胞中形成的，例如癌细胞， 灵敏的电极可以用于癌症的早期检测。这些 我们的纳瓦霍学生对疾病很感兴趣，因为 美洲印第安人的糖尿病发病率相当高。癌症是 所有群体都感兴趣的。 我们的方法是在有机半导体中建立探测器 已为特定生物分子模板化的基质。对于葡萄糖， 模板将由含有硼酸盐的单体制成； 二胺模板将由含有羧基的单体制成。这个 半导体聚合物主干将由聚噻吩和 聚吡咯。 这项研究的第二个目标是土著居民的参与 参与该项目的美国学生。我们一直在参与 过去十年来一直是美国原住民学生，并希望继续下去。 每个学生都将得到自己的项目，开发它，写下它，并 在科学会议上展示这些信息。学生们将成为 被允许就研究做出决定并参与写作 科学论文。

One of the objectives of this research is to develop the necessary basic research to allow the construction of biomolecule sensitive electrodes. Such electrodes, if they could be used in-vivo to monitor blood glucose levels, could be used to regulate insulin flow in diabetic patients. Another class of biomolecules that are of interest are certain diamines. Some diamines are formed in rapidly dividing cells, such as cancer cells, and a sensitive electrode could be used for early cancer detection. These diseases are of interest to our Navajo students as the incidence of diabetes in Native American Indian populations is quite high. Cancer is of interest to all groups of people. Our approach is to build our detectors in an organic semiconducting matrix which has been templated for a specific biomolecule. For glucose, the templates will be made from a borate containing monomer; for the diamine the templates will be made from a carboxyl containing monmer. The semiconducting polymer backbone will be made from polythiophene and polypyrrole. The second objective of this research is the involvement of Native American students in the project. We have had an ongoing involvement with Native American students for the past ten years and wish to continue. Each student will get their own project, develop it, write about it and present the information at scientific meetings. The students will be allowed to make decisions about the research and be involved in writing scientific papers.