Contribution of MDSC-derived cysteine cathepsins in breast cancer metastasis to bone

组织蛋白酶是一种被称为蛋白酶的酶，它的功能是切割特定的蛋白质，这一过程对许多正常的细胞功能都很重要。组织蛋白酶活性异常可导致多种病理，包括癌症和炎症。我们正在开发一种叫做基于活性的探针的工具来研究组织蛋白酶在疾病中的功能。具体来说，我们将研究它们在免疫系统细胞内的活性，以开发新的治疗方法。

Cathepsins are enzymes called proteases that function to cleave specific proteins, a process that is important for many normal cellular functions. Aberrant cathepsin activity can result in a number of pathologies, including cancer and inflammation. We are developing tools called activity-based probes to study the function of cathepsins in disease. Specifically, we will investigate their activity within cells of the immune system with the goal of developing novel therapeutic approaches.