PHYSIOLOGY OF BONE METABOLISM IN AN AGING POPULATION

骨质疏松症是老年人的主要问题。 这是一 老年人骨代谢生理学的多学科研究 长期目标是更好地了解 的病因，并制定更好的方法来预防和治疗与年龄有关的 骨质流失 项目1（“骨丢失相关类型的病理生理学”） 将试图描述更年期综合征的病理生理学和病因学， 骨质疏松症，并将基于控制和 马约综合临床研究中心的神经病受试者。 项目2（“老年人髋部骨折的危险因素”）包括 一系列大型流行病学回顾性队列研究， 试图确定特定患者中的共同病因因素， 疾病和外科手术，已显示在初步 研究对髋部骨折的发展有实质性的贡献 在老年人中。 基于这些发现，可检验的假设， 发病机制将得到发展。 项目3（“非胶原骨基质 蛋白质”）将寻求识别和表征骨特异性蛋白质， 骨基质的非胶原成分可能具有重要的 维持骨结构和/或调节骨细胞的作用 功能 衰老对这些蛋白质的骨含量的影响将 也要检查。 项目4（“骨特异性免疫化学定量 Proteins”）将寻求发展单克隆和多克隆放射免疫分析 用于测量骨特异性蛋白质的系统。 这些将是 通过与现有方法（包括骨）的比较进行验证 组织形态计量学和放射性钙动力学研究， 骨丢失疾病受试者。 这些标志物将对 实施骨代谢研究，涉及大量的 老年受试者，由于年老体弱， 骨活检、放射性钙动力学和钙平衡的候选者 问题研究 一个行政和生物统计核心单位将提供 开展四个项目所需的统计支助，以及 其他一般支持项目。

Age-related bone loss is a major problem for the elderly. This is a multidisciplinary study of the physiology of bone metabolism in the aging population which has as its long-term goal to gain better understanding of the etiology and to develop better ways to prevent and treat age-related bone loss. Project 1 ("Pathophysiology of Types of Age-Related Bone Loss") will seek to characterize the pathophysiology and etiology of involutional osteoporosis and will be based on intensive studies of control and osteoporotic subjects in the Mayo General Clinical Research Center. Project 2 ("Risk Factors for Hip Fracture Among the Elderly") consists of a series of large epidemiologic retrospective cohort studies which will attempt to identify common etiologic factors among patients with specific disease and surgical procedures which have been shown in preliminary studies to contribute substantially to the development of hip fractures among the elderly. Based on these findings, testable hypotheses of pathogenesis will be developed. Project 3 ("Noncollagenous Bone Matrix Proteins") will seek to identify and characterize bone specific proteins in the noncollagenous component of bone matrix which could have important roles in maintaining bone structure and/or in regulating bone cell function. The effect of aging on the bone content of these proteins will also be examined. Project 4 ("Immunochemical Quantitation of Bone Specific Proteins") will seek to develop monoclonal and polyclonal radioimmunoassay systems for measurement of the bone specific proteins. These will be validated by comparison with existing methodologies including bone histomorphometry and radiocalcium kinetic studies in normal subjects and subjects with bone losing diseases. These markers will be crucial for implementing studies on bone metabolism that involve large numbers of elderly subjects who, because of the infirmities of age, are poor candidates for bone biopsy, radiocalcium kinetic, and calcium balance studies. An administrative and biostatistical core unit will provide the statistical support required to carry out the four projects as well as some other general support items.