CHEMICAL SYNTHESIS OF RADIOLABELED ANTITUMOR AGENTS

承包商应提供并运营一个制备实验室 用于合成1至50毫居里的放射性标记材料 项目负责人（PO）指定的数量。 优先事项 准备工作将从PO开始。 NCI的PO将 在每次请求时发送化合物的名称和结构 所分配的数量和制备方法（当 可用）和其他相关信息。 特定分析 承包商进行的试验可由 PO. 如有必要，承包商应获取并纯化某些 不同量的市售放射性标记材料 如PO所选。 承包商应分析材料 必要时制备、获得或储存，以确保效力 纯度和保质期。 承包商应提供准备 所有适用材料的分析方法和分析数据表， 格式为PO所接受。 承包商应提供适当的存储这些 放射性标记的化合物。 大多数材料都储存在-70度 在一个安全的监控冰箱里。 将对此类材料进行分析 和/或根据需要再纯化。 承包商应称重， 重新包装、标记和运输规定数量的放射性标记的 材料提供给位于不同实验室的合格研究者 全国各地的诊所。 所有请求必须 由PO或其指定人员授权。

The contractor shall provide and operate a preparation laboratory for the synthesis of radiolabeled materials in 1 to 50 millicurie quantities as assigned by the Project Officer (PO). Priorities for preparation will originate with the PO. The PO for the NCI will transmit with each request a name and structure of the compound assigned, quantity desired and method of preparation (when available), and other pertinent information. Particular analytical tests to be performed by the contractor may be specified by the PO. The contractor shall obtain and purify, if necessary, certain commercially available radiolabeled materials in varying amounts as selected by the PO. The contractor shall assay materials prepared, obtained or stored as necessary, to insure potency purity and shelf life. The contractor shall provide preparative methods and analytical data sheets on all applicable materials in a format acceptable to the PO. The contractor shall provide suitable storage for these radiolabeled compounds. Most materials are stored at -70 degrees C in a secure monitored freezer. Such material will be assayed and/or repurified, as needed. The contractor shall weigh, repackage, label and ship specified quantities of radiolabeled materials to qualified investigators located in various laboratories and clinics throughout the country. All requests must be authorized by the PO or his designee.