CHEMICAL SYNTHESIS OF C14, H3 AND S35 LABELED ANTI-AIDS

维持和经营一个专门的实验室， 选择的用碳-14标记的抗癌和抗AIDS化合物， 氚或硫-35。 开发选定的此类药物的放射合成 NCI的。 标签将被结合在包装的期望位置处。 分子通过仔细选择的合成序列或通过合适的 交换程序。我们将集中精力寻找最佳的 在非放射性和/或示踪剂中进行这种标记的条件 实验 然后将最佳反应条件应用于 放射性物质的制备性合成。 特别 将注意实现高摩尔比 放射性和化学和放射化学纯度（> 98%）。 维护完整的数据表和详细的实验室记录 程序或个别产品。 所有化合物将储存在 最适合每种产品的条件，包括储存在 防止辐射分解的溶剂，并在-80 ℃的冰箱中储存 致力于这个项目。 放射性标记化合物的特定量 在本项目中合成，将由联邦快递运送到 指定的调查员。 包装和运输将符合 美国交通部的规定。

Maintain and operate a specialized laboratory for the synthesis of selected anti-cancer and anti-AIDS compounds labeled with carbon-14, tritium or sulfur-35. Develop the radiosynthesis of such drugs selected by NCI. The label will be incorporated at a desirable site of the molecule by a carefully selected synthetic sequence or by a suitable exchange procedure. Efforts will concentrate on finding optimal conditions for such labeling in non-radioactive and/or tracer experiments. The optimum reaction conditions will then be applied to the synthesis of radioactive materials on preparative scale. Special attention will be paid to the achievement of high molar specific radioactivity and chemical and radiochemical purity (>98%). Maintain complete data sheets and records of detailed laboratory procedures or individual products. All compounds will be stored at conditions most suitable for each product, including storage in radiolysis preventing solvents and storage at -80 degrees in a freezer dedicated to this project. Specific amounts of radiolabeled compounds synthesized in this project, will be shipped by Federal Express to designated investigators. Packaging and shipping will comply with the regulations of US Department of Transportation.