CANCER IN PATIENTS WITH ATAXIA-TELANGIECTASIA

这项记录联动调查的目标是(10)汇编一份 被诊断为共济失调-毛细血管扩张(AT)的患者名单；(2) 评估这些人的癌症发生情况；(3)确定 一级亲属(父母、子女和兄弟姐妹)，二级亲属 在可行的范围内(祖父母、阿姨、叔叔、叔叔和 表)，并将这些亲属的名册与癌症登记记录联系起来 确定癌症的发生；以及(4)采集血液和组织 用于分子评估的患者及其亲属的样本。一个 分子评价将提供有关该蛋白作用的重要知识。 致癌过程中的遗传易感性。

The objectives of this record-linkage investigation are (10 to assemble a roster of patients who were diagnosed with ataxia-telangiectasia (AT); (2) to evaluate the occurance of cancer in these individuals; (3) to identify first degree relatives (parents, offspring, and siblings), and second degree relatives to the extent feasible (grandparents, aunts, uncles, and cousins) and link rosters of these relatives to cancer registry records to determine the occurrence of cancers; and (4) to obtain blood and tissue samples on patients and their relatives for molecular evaluation. A molecular evaluation will provide important knowledge on the role of genetic predisposition in the carcinogenic process.