课题基金 / 基金详情

CANCER FOLLOWING BONE MARROW TRANSPLANTATION

CANCER FOLLOWING BONE MARROW TRANSPLANTATION
骨髓移植后的癌症
批准号：
2600923
负责人：
H. JOACHIM DEEG
金额：
$11.22万
依托单位：
FRED HUTCHINSON CANCER RESEARCH CENTER
依托单位国家：
美国
项目类别：
财政年份：
1995
资助国家：
美国
项目状态：
已结题
起止时间：
1995-09-30 至 1998-09-29
来源：
https://reporter.nih.gov/project-details/2600923
关键词：
age difference artificial immunosuppression autologous transplantation bone marrow transplantation cancer risk graft versus host disease human subject human therapy evaluation immunosuppressive neoplasm /cancer immunology radiation immunosuppression radiation related neoplasm /cancer whole body irradiation dosage

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中文摘要
翻译
评价免疫抑制和全身治疗对机体的影响 放射和化疗对骨后新发恶性肿瘤风险的影响 骨髓移植。一种新的技术的发展与 癌症，特别是新的实体肿瘤和长期的免疫抑制 将估计慢性移植物抗宿主病和/或高剂量辐射。癌 未暴露于免疫抑制的患者队列中的风险 (自体移植)将接受评估。不同年龄的风险差异 移植和移植后的时间将被量化。
英文摘要
To evaluate the influence of immunosuppression and therapy with whole body irradiation and chemotherapy on the risk of new malignancies following bone marrow transplantation. The association between development of a new cancer, in particular, new solid tumors, and prolonged immune suppression from chronic GVHD and/or high dose radiation will be estimated. Cancer risk among the cohort of patients not exposed to immune suppression (autologous transplants) will be evaluated. Variation in risk by age at transplantation and time after transplantation will be quantified.
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Hematopoietic Cell Transplantation and Iron Overload
Hematopoietic Cell Transplantation and Iron Overload
Hematopoietic Cell Transplantation and Iron Overload
Hematopoietic Cell Transplantation and Iron Overload