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Control of Immunoreceptor Assembly and Function by Intramembrane Sequence Elements

Control of Immunoreceptor Assembly and Function by Intramembrane Sequence Elements
膜内序列元件对免疫受体组装和功能的控制
批准号:
nhmrc : 1011352
负责人:
A/Pr Matthew Call
金额:
$26.88万
依托单位国家:
澳大利亚
项目类别:
Project Grants
财政年份:
2011
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2011-01-01 至 2013-12-31

项目摘要

项目成果

A/Pr Matthew Call的其他基金

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中文摘要
翻译
免疫系统的细胞不断地观察周围环境的变化,寻找表明受损的迹象。为了感知周围环境,细胞使用了一系列与信号转接器蛋白相关的受体,当受体结合配体时,信号转接器蛋白在细胞内启动信号级联反应。本项目旨在确定免疫细胞质膜上信号传播的结构机制。
英文摘要
The cells of the immune system constantly survey their environment for changes that indicate damage. To sense their surroundings cells employ a host of receptors that are associated with signalling adapter proteins that initiate signalling cascades inside the cell when receptors bind ligands. This project seeks to determine the structural mechanisms of signal propagation across the plasma membrane of immune cells.
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会议论文
Structural Basis of Substrate Recognition by the Membrane-Associated E3 Ubiquitin Ligases
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