STATISTICAL ANALYSIS OF LABORATORY ANIMAL STUDIES

本合同的目标是提供统计和 计算专业知识和资源，以总结、分析和帮助 对各种实验动物实验数据的解释 由国家毒理学计划(NTP)进行。这些调查 包括亚慢性研究、致癌实验和其他 毒物学研究。 对NTP亚慢性研究的评估包括提供统计 生存分析，器官和体重，临床化学， 血液学和病理学观察，这些变量用于 长期致癌实验剂量的选择。这个 承包商还通过以下方式为NTP生殖评估提供支持 连续育种项目及其他专题研究。 对于NTP长期研究，承包商有责任 毒理学数据统计软件的开发与维护 管理系统(TDMS)。这包括开发和维护 分析肿瘤发病率和存活率的程序，并提供 食物和水的消耗以及体重增加的汇总统计。这个 承包商还负责维护历史数据库 控制肿瘤发病率。

The objectives of this contract are to provide statistical and computational expertise and resources to summarize, analyze and aid in the interpretation of data from various laboratory animal experiments conducted by the National Toxicology Program (NTP). These investigations consist of subchronic studies, carcinogenesis experiments and other toxicological studies. Evaluation of NTP subchronic studies consists of providing statistical analyses of survival, organ and body weights, clinical chemistry, hematology, and pathology observations, variables which are used in the selection of doses for long-term carcinogenicity experiments. The contractor also provides support to the NTP Reproductive Assessment by Continuous Breeding Project and other special studies. For NTP long term studies, the contractor has responsibility for developing and maintaining statistical software for the Toxicology Data Management System (TDMS). This includes developing and maintaining programs for the analysis of tumor incidence and survival and providing summary statistics for food and water consumption and weight gain. The contractor is also responsible for maintaining a data base on historical control tumor incidence.