Resilience In PreTerm Infants during DEvelopment (RIPTIDE)

早产（<37周妊娠）率正在上升。虽然生存率大大提高，但长期结果在过去几十年中并没有改善。特别是极早产（VP）出生的儿童（<32周）处于发育障碍的高风险中，这些障碍在整个发育过程中持续存在，并给个人，家庭和社会带来巨大负担。早产及其后果几乎完全是从生物医学的角度来研究的，从而忽视了社会和环境因素在儿童发育中的重要作用，主要集中在缺陷和问题上。然而，大约一半的VP出生的孩子显示出适应性结果（即弹性）。RIPTIDE旨在提供对VP出生后促进恢复力的顺从因素的见解。该项目使用基于人口的队列数据，研究儿童和青少年的学术和心理健康复原力以及儿童系统多层次的复原力因素。此外，还将研究复原力因素的动态变化和随后的结果，沿着儿童可以获得的复原力资源系统。根据性别和环境逆境的不同影响将进行审查，以了解亚群体的需求。最后，将把利益攸关方的观点与研究结果结合起来，以制定政策优先事项，为面临风险的儿童提供多方面的支助。MSCA-PF将使我能够在早产研究中开辟这种新的弹性途径。RIPTIDE的见解将为制定干预措施和政策做出重要贡献，促进所有VP出生儿童的积极发展，包括代表性不足的群体。在沃里克大学和经合组织执行这个项目将是一个独特的机会，可以扩展我的技能，增强我在科学内外的职业前景，缩小研究政策差距，为改善副总裁出生后的成果做出宝贵贡献。

Preterm birth (<37 weeks' gestation) rates are rising. Although survival rates have largely increased, long-term outcomes have not improved over the last decades. Especially very preterm (VP) born children (<32 weeks) are at high risk for developmental impairments that persist throughout development and put a large burden on individuals, families, and society. Preterm birth and its consequences have almost exclusively been studied from a biomedical perspective, thereby neglecting the important role of social and environmental factors in child development and mainly focusing on deficits and problems. However, roughly half of the VP born children shows adaptive outcomes (i.e. resilience). RIPTIDE aims to provide insight in amenable factors that promote resilience after VP birth. The project uses data from population-based cohorts to study academic and mental health resilience in childhood and adolescence and resilience factors at multiple levels of the child's system. Moreover, dynamic change in resilience factors and subsequent outcomes will be studied, along with the system of resilience resources that a child has access to. Differential effects according to sex and context adversity will be examined to give insight in the needs of subgroups. Lastly, stakeholders' perspectives will be integrated with research findings to formulate policy priorities for multidimensional support for at-risk children. MSCA-PF would enable me to open-up this new avenue of resilience in preterm birth research. Insights from RIPTIDE will make an important contribution to the development of interventions and policies that promote positive development of all VP born children, including underrepresented groups. Executing this project at the University of Warwick and the OECD would be a unique opportunity to expand my skills set, enhance my career perspectives within and outside science, and narrow the research-policy gap to make a valuable contribution to improving outcomes after VP birth.