CELLULAR AND MOLECULAR STUDIES OF AUTOIMMUNE DISEASES

这四个环环相扣的合作项目的总体目标是， 研究实验和人类自身免疫的细胞和分子基础 疾病 血清学、细胞学、生物化学和分子生物学技术将在 用于分析编码特异性的基因及其产物， 硬皮病和肠道疾病患者的自身抗体，II类 抗原，以及关键分子发挥重要作用， Fc受体等细胞协同作用。 此外，Cell 抗原呈递细胞和主要亚群之间的合作 介导体液或细胞自身免疫应答的淋巴细胞将 通过细胞、生物化学和分子生物学方法进行研究。 每个 个别项目的主要目的是提供重要的见解， 自身免疫性疾病的发病机制。

The overall goal of these four interlocking and cooperative projects is to study the cellular and molecular basis of experimental and human autoimmune disease. Serologic, cellular, biochemical and molecular biology techniques will be used to analyze the genes and their products encoding the specificity of autoantibodies in patients with scleroderma and bowel diseases, class II antigens, as well as of critical molecules which play an important role in the cell cooperation such as the Fc receptor. Furthermore, cell cooperation between antigens presenting cells and major subpopulations of lymphocytes mediating either humoral or cellular autoimmune response will be studied by cellular, biochemical and molecular biology approaches. Each individual project has a major aim to provide important insights in the pathogenesis of autoimmune disease.