Tubular Supramolecular Polymer Brushes Delivery Vectors

近年来，纳米结构已成为现代医学的关键参与者，这是由于其作为药物递送载体的众多优势超过了传统的递送系统，其应用范围从医学成像中的造影剂到基因递送载体到单个细胞。特别是，纳米颗粒（NPs）的研究探索了如何通过深入了解纳米颗粒与细胞的相互作用以及最佳毒性或浓度来使药物更有效。与传统药物相比，增强的药代动力学、生物相容性、肿瘤靶向和稳定性与基于NP的药物递送系统相关，同时在最小化全身毒性和克服耐药性方面发挥重要作用。然而，与选择性结合、靶向递送和毒性相关的许多问题需要克服。特别是，主要的挑战仍然是实现正确的平衡安全性/有效性和提高给定药物的治疗指数。一旦纳米粒子释放了它们的有效载荷，它们必须被设计为降解，以避免器官积累，通常是肝脏和脾脏，导致毒性和长期健康问题。本申请旨在解决这一问题，通过建立在ERC Consolidator赠款TUSUPO的一部分开发的材料。这些材料可以有效地传递抗癌药物，延长体内循环时间，最终分解为无毒成分，可以排出体外。本项目将扩大这些材料的应用范围，并建立其药代动力学数据，这是将其推向临床和市场的关键。

Nanostructures have emerged as key players in modern medicine in recent years, due to their numerous advantages employed as drug delivery vectors over conventional delivery systems, with applications ranging from contrast agents in medical imaging to gene delivery carriers to individual cells. In particular, research in nanoparticles (NPs) has explored how to make drugs more effective by having an in-depth understanding of the interaction of nanoparticles with cells, and the optimal toxicity or concentration. Compared to traditional drugs, enhanced pharmacokinetics, biocompatibility, tumour targeting, and stability are associated with NP-based drug delivery systems, while simultaneously playing an important role in minimizing systemic toxicity and overcoming drug resistance. However, many problems related to selective binding, targeted delivery and toxicity need to be overcome. In particular, the main challenge still remains achieving the correct balance safety / efficacy and improving the therapeutic index of a given drug. Once the NPs have delivered their payload, they must be engineered to degrade, to avoid organ accumulation, typically liver and spleen, causing toxicity and long-term health issues. This PoC application aims at addressing this issue, by building on the materials developed as part of the ERC Consolidator grant TUSUPO. These materials can effectively deliver anticancer drugs, have prolonged circulation time in vivo and eventually disassemble in non-toxic component which can be excreted. This project will expand the application of these materials and established their pharmacokinetic data, which are key to take them to clinic and market.