AIDS RESEARCH

这份申请是为了在杜克大学建立一个艾滋病研究中心 汇集了超过30名独立调查人员的才能， 学术部门。他们都从事艾滋病或与艾滋病有关的研究。 多学科的代表，但科学计划是 主要分为四个方面：（1）宿主HIV-1的分子机制 相互作用，（2）HIV蛋白的免疫原性表位，（3）细胞 对HIV-1感染的反应和（4）其他人类逆转录病毒， HIV-1致病性中的感染因子。基础科学课程 与临床研究项目密切互动，其中包括 成人和儿童组件。基础和临床研究项目 由七种核心资源提供动力，这些资源在（1）基因方面提供支持 表情(2)肽合成，（3）逆转录病毒生物学，（4）流动 细胞计数，（5）Scid-Hu/转基因小鼠模型，（6）数据管理和（7） 人类研究材料的采购和方案设计。其余 组件代表未来增长和发展的计划，评估 和行政管理。

This application to develop a Center for AIDS Research at Duke University assembles the talents of over thirty independent investigators within six academic departments. All are engaged in AIDS or AIDS related research. Multiple disciplines are represented but the scientific programs are organized into four broad areas: (1) molecular mechanisms of host-HIV-1 interactions, (2) immunogenic epitopes of HIV proteins, (3) cellular responses to HIV-1 infection and (4) other human retroviruses and infectious agents in HIV-1 pathogenicity. The basic science programs interact closely with the clinical research program which includes both adult and pediatric components. Both basic and clinical research programs are fueled by seven core resources which provide support in (1) gene expression. (2) peptide synthesis, (3) retroviral biology, (4) flow cytometry, (5) Scid-Hu/transgenic mouse models, (6) data management and (7) procurement of human research material and protocol design. The remaining components represent plans for future growth and development, evaluation and administration.