MetRaZymes: Metal-containing Radical Enzymes

制药、化学和聚合物工业是欧洲经济的基石。他们向更可持续的过程和创新的新化合物过渡的一个关键因素是生物催化。特别感兴趣的是金属酶，即含有金属辅助因子的蛋白质。它们催化多种氧化还原反应和自由基反应。为了获得自然界中未知的反应，可以创造人工金属酶。它们将金属配合物的新自然催化活性与活性蛋白位点的选择性诱导环境相结合。为了开发新的生物催化剂，需要高度跨学科的技能。MetRaZymes将在欧洲领先的大学中建立一个博士学院，培养能够以整体方法解决新型酶反应的设计，开发和实施的下一代科学家。它汇集了计算生物科学家，生物无机和聚合物化学家，以及生物过程工程师。以人工金属酶和再利用金属酶为重点，ESRs将为具有高合成价值的自由基反应开发新型生物催化剂，如药物中间体的后期修饰或由可再生单体合成聚合物。为了培训esr满足工业生物技术的需求，该联盟包括8家欧洲领先的制药、化学和酶学公司。esr将受益于由五个培训合作伙伴提供的大规模可转移技能培训计划。亮点包括自然大师班和维基百科研讨会。像维基媒体和工业生物技术创新中心这样的交流伙伴将作为结果交流的倍增器。此外，esr将与以生物学为表达方式的艺术家合作，创建一个ARTzymes展览，以培养ERS的创造力，并与公众形成一种独特的科学对话形式

The pharmaceutical, chemical and polymer industries are cornerstones of Europe's economy. A key element for their transition to more sustainable processes and to innovative new compounds is biocatalysis. Of particular interest are metallo-enzymes, i.e. proteins that host a metal cofactor. They catalyze a multitude of redox and radical reactions. To access reactions that are unknown in nature, artificial metallo-enzymes can be created. They combine the new-to-nature catalytic activity of metal complexes with the selectivity-inducing environment of the active protein site. To develop novel biocatalysts, a highly interdisciplinary skill set is needed. MetRaZymes will create a PhD school across leading European universities that will train the next generation of scientists capable of tackling the design, development and implementation of novel enzymatic reactions in a holistic approach. It brings together computational bioscientists, bioinorganic and polymer chemists, and bioprocess engineers. Using artificial and repurposed metalloenzymes as the focal point, the ESRs will develop novel biocatalysts for radical reactions of high synthetic value, such as the late stage modification of pharmaceutical intermediates or the synthesis of polymers from renewable monomers. To train the ESRs in the needs of industrial biotechnology, the consortium includes eight of Europe's leading pharmaceutical, chemical and enzymology companies. The ESRs will benefit from a vast transferable skills training program delivered by five training partners. Highlights include a Nature Masterclass and Wikipedia workshop. Communication partners such as Wikimedia and the Industrial Biotechnology Innovation Centre will act as muliplicators for the communication of results. Moreover, the ESRs will work with artist that use biology as their way of expression to create an ARTzymes exhibition that will foster the ERS's creativity and result in a an unique form of science dialogue with the general public