ALCOHOL, INFECTION, AND HOST RESPONSE

这份酒精研究中心的建议书，题为“酒精感染和 主机响应“，是一组积极的、 独立、原创的科学家将他们的智力和 物力资源，打造地区性酒精中心，将改善 他们的科学效率和生产力，并将作为一个区域 与酒精有关的研究、教育和教育领域的资源 信息传输。拟建中心的研究工作将 重新加强和扩大目前对酒精的现有调查- 路易斯安那州立大学医学中心的相关研究和制作 它们更具跨学科的特点。参与调查的高级调查员是 提出三项重大科学计划，题为：(1) “酒精与机体防御相关的肝功能”，(2)“酒精， 免疫抑制与宿主防御“，以及(3)”酒精诱导的调节“ 细胞因子和一氧化氮在大鼠肺中的作用“。 提议：a)行政核心；b)动物核心设施交易 手术准备，以及喂食和处理 慢性酒精中毒动物；c)组织培养的实验室核心 和分析组件。核心单位也将有一个主要的 对目前由NIAAA资助的研究的有利影响 几名调查人员的活动。此外，还有四个试点项目 包括在提案中，以及其他几个 未来可能的试点项目。后者包括一项提案 这最终将导致临床研究利用可用的 综合临床研究中心，以及研究和培训 泽维尔大学教职员工和学生的机会 以黑人为主的机构。最后，研究的一个重要组成部分 培训和信息传递也是 建议的ARC。这个急需的区域中心将做出巨大贡献 为了加深我们对代谢和免疫损伤的理解 酒精滥用对我们的人口造成的后续损害。

This Alcohol Research Center proposal, entitled "Alcohol Infection and Host Response", is a coordinated effort on the part of a group of active, independent, original scientists to combine their intellectual and physical resources to create a regional alcohol center that will improve their scientific efficiency and productivity and will serve as a regional resources in the field of alcohol-related research, education and information transfer. The research efforts of the proposed Center will re-enforce and expand the currently existing investigations of alcohol- related research at Louisiana State University Medical Center and make them more interdisciplinary. The participating senior investigators are proposing three major scientific projects that are entitled: (1) "Alcohol ad host defense related hepatic function", (2) "Alcohol, immunosuppression and host defense", and (3) "Alcohol-induced modulation of cytokines and nitric oxide in rat lung". Three Core Units are proposed: a) an Administrative Core; b) an Animal Core facility dealing with the surgical preparation, as well as the feeding and handling of the chronic alcoholic animals; and c) a Laboratory Core with tissue culture and analytical components. The Core Units will also have a major beneficial impact on the presently funded NIAAA-supported research activities of several investigators. In addition, four Pilot Projects are included in the proposal, as well as brief outlines of several other potential future Pilot Projects. The latter group includes a proposal that will eventually result in clinical studies utilizing the available General Clinical Research Center, and also research and training opportunities for faculty and students of Xavier University, a predominantly black institution. Finally a strong component of research training and information transfer is also an integral part of the proposed ARC. This much-needed regional center will greatly contribute to our understanding of the metabolic and immunologic impairments and subsequent damage that alcohol abuse inflicts upon our population.