SPECIAL PROJECT ON RESEARCH EXCELLENCE--BREAST CANCER

本文档描述了我们的SPORE应用程序，标题为“用于 乳腺癌的预防和治疗。 该计划基于 前提是参与有丝分裂、侵袭和转移的分子 乳腺癌的行为以及逃避激素依赖是 可识别并因此可用于改进的识别， 治疗选择和治疗的特定生物疗法的设计 和预防疾病。 在这个应用程序中， 研究项目的重点是扩大我们对 这些分子在乳腺癌进展中的发病学意义 并利用这些信息来制定有效的新策略， 乳腺癌的预防和治疗。 选择的具体目标 转化研究包括肝素结合生长因子 肿瘤诱导的血管生成所需的（因此在转化中至关重要）。 从原位到浸润性乳腺癌）;一种新的金属蛋白酶分泌 乳腺癌细胞;新发现的erbB 2配体，可能发挥作用， 在乳腺癌进展和治疗抵抗中的作用，以及雌激素 受体的 预后因素的临床前和临床研究， 开发了涉及这些乳腺癌产品的疗法。 一系列 描述了四种新的核心，包括新鲜和冷冻的肿瘤库， 乳腺肿瘤材料，乳腺癌细胞系库，临床 乳腺癌研究资源和独特的研究机制 协调支持这些项目并促进与其他 机构优势和其他SPORE。 一个持续的计划 发展的教师致力于乳腺癌的研究是描述 年轻教师的具体例子和他们的工作，这将有利于 从这个节目中。 高优先级试点项目组合 与系统的优先次序和监督进行了讨论， 直接参与主要的SPORE项目和转化研究 活动 最后，一个协调一致、结构严密的组织， 描述了SPORE，它提供了问责制、灵活性和最佳的 在SPORE内部，在机构结构内部，以及与 其他SPORE，以实现改善面临风险的妇女前景的目标。 乳腺癌和已经患有这种疾病的患者。

This document describes our SPORE application entitled "Novel Targets for Prevention and Therapy of Breast Cancer". This program is based on the premise that molecules involved in the mitogenic, invasive and metastatic behavior of breast cancer as well as escape from hormone independence are identifiable and thus can be exploited for improved prognostication, therapy selection, and design of specific biologic therapies for treatment and prevention of disease. In this application a series of interactive research projects are focused on expanding our understanding of the pathogenetic significance of these molecules in breast cancer progression and exploiting this information to develop effective new strategies for breast cancer prevention and treatment. Specific targets chosen for translational research studies include heparin binding growth factors required for tumor induced angiogenesis (and thus critical in conversion from in situ to invasive breast cancer); a novel metalloproteinase secreted by breast cancer cells; newly discovered ligands of erbB2 which may play a role in breast cancer progression and therapy resistance, and the estrogen receptor. Preclinical and clinical studies of prognostic factors and therapies involving these breast cancer products are developed. A series of four novel cores is described including a tumor bank of fresh and frozen breast tumor materials, a repository of breast cancer cell lines, clinical breast cancer research resources and a unique mechanism of research coordination which support these projects and foster interaction with other institutional strengths and other SPOREs. A program for continued development of faculty committed to breast cancer research is described with specific examples of young faculty and their work which will benefit from this program. A portfolio of high priority pilot projects together with a system for prioritization and oversight is discussed which contribute directly to major SPORE projects and translational research activities. Finally, a coherent, tightly structured organization for the SPORE is described which provides accountability, flexibility and optimal interaction within the SPORE, within the institutional structure, and with other SPOREs to achieve the goal of improved outlook for women at risk of breast cancer and for patients already suffering from the disease.