IOWA COCHLEAR IMPLANT PROJECT II

这一竞争性续订申请要求继续临床和 基础研究评价不同的人工耳蜗术。九十个- 5名语后深度失聪的成年人植入了3种不同的 多通道假体将进行受试者内的临床试验 语音处理策略。其次，45名语言前期严重失聪的人 儿童(2-13岁)将植入多通道人工耳蜗 以确定植入时的年龄是否会影响结果。这 合作努力涉及五个领域的调查：听力学， 心理学、听觉康复、电生理学和言语产生。 听力学表现将在短期和长期后进行评估 具有模拟或交错脉冲式语音处理经验 使用MiniMed和Lnerald人工耳蜗术的算法。核心用户将 参与一项对比两种语音处理策略的试验。 心理学研究将评估人们的行为和情绪 人工耳蜗植入对成人和儿童的影响。 可能预测植入物使用的心理变量将是 评估过了。成人听力康复项目将决定 康复方法之间的差异和评估康复方法的重要性 沟通策略。术中措施之间的关系 使用植入物的耳蜗神经动作电位和表现 在一个电生理学项目中探索。动物研究将被用来 相关电生理测量与外周形态的关系 听觉系统。儿童听力康复与言语产生 项目将评估年龄和以家庭为基础的相对贡献 康复到结果。 研究计划的总体目标包括：1)优化言语 针对单个主题的编码算法会降低性能 变异性；2)发展电生理和心理测量 预测结果；3)提供多渠道的长期随访 种植体接受者；4)评估种植体编码策略和 关于沟通功能的视听培训；5)测量效用 有关提高多通道人工耳蜗植入物性能的方法 并确定年龄对儿童听力的影响 植入。

This competing renewal application requests continuation of clinical and basic research evaluating different cochlear implant prostheses. Ninety- five postlingual profoundly deaf adults implanted with 3 different multichannel prostheses will be engaged in a within-subject clinical trial of speech processing strategies. Secondly, 45 prelingually profoundly deaf children (2-13 years of age) will be implanted with multichannel cochlear implants to determine if the age at implantation affects outcome. This collaborative effort involves five areas of investigation: audiology, psychology, aural rehabilitation, electrophysiology, and speech production. Audiologic performance will be evaluated after brief and long-term experience with either analogue or interleaved pulsatile speech processing algorithms using MiniMed and lnerald cochlear implants. Nucleus users will participate in a trial contrasting two speech processing strategies. Psychological studies will evaluate the behavioral and emotional consequences of cochlear implants in both adults and children. Psychological variables that may be predictive implant use will be assessed. The adult Aural Rehabilitation Project will determine differences between rehabilitation approaches and assess the importance of communication strategies. The relationship between intraoperative measures of cochlear nerve action potentials and performance with an implant will be explored in an electrophysiologic project. Animal studies will be used to correlate electrophysiologic measures and morphology of the peripheral auditory system. A children's aural rehabilitation and speech production project will assess the relative contribution of age and home-based rehabilitation to outcome. The overall objectives of the research program include: 1) optimize speech coding algorithms for individual subjects to reduce performance variability; 2) develop electrophysiologic and psychologic measures predictive of outcome; 3) provide long-term follow-up of multichannel implant recipients; 4) assess the impact of implant coding strategies and audiovisual training on communication functioning; 5) measure the utility for methods of enhancing performance of multichannel cochlear implants in prelingually deafened children and determine the effect of age at implantation.