SODIUM PUMP INHIBITORS IN CARDIOVASCULAR CONTROL

越来越多的证据表明，洋地黄样因子(EDLF)可能在 在心血管疾病发病机制中的重要作用 (高血压、充血性心力衰竭、急性心肌梗死)通过 它们抑制钠泵活动的能力。一直以来，人们都在关注 其中一个因素是内源性哇巴因；然而，地高辛- 类似的免疫反应因子此前也被发现与 心肌缺血时心律失常的发生。这个项目的目标是 是为了阐明各种钠泵抑制剂的作用，特别是 地高辛样免疫反应EDLF，在血压调节中的作用。 在过去的一年里，对麻醉犬的研究已经完成 显示内源性洋地黄样因子的增加，这些因子是 由血浆体积迅速膨胀引起的，包括蟾酥二烯内酯 比同时观察到的地高辛浓度更高的化合物 相似的因素。用抗洋地黄抗体对动物进行预处理 防止快速发展的心脏收缩能力的增加和 钠尿症进展较慢。第二项研究表明，自愿的 受试者的低通气性呼吸由一种反馈维持 呼吸气体监测也与尿量增加有关 蟾酥二烯内酯化合物排泄持续30分钟 在呼吸任务停止后。这些研究已经 对理解高血压的起源和对 心血管疾病新的药理干预研究进展 精神错乱。

Evidence has accumulated that digitalis-like factor (EDLF) may play an important role in the pathogenesis of cardiovascular disease (hypertension, congestive heart failure, acute myocardial infarction) via their ability to inhibit sodium pump activity. Much attention has been paid to one of these factors, an endogenous ouabain; however, a digoxin- like immunoreactive factor has also been found previously to contribute to arrythmogenesis in myocardial ischemia. The objectives of this project are to clarify the role of various sodium pump inhibitors, especially the digoxin-like immunoreactive EDLF, in blood pressure regulation. During the past year, studies were completed with anesthetized dogs which showed that the increases in endogenous digitalis-like factors, which are evoked by rapid expansion of plasma volume, include a bufodienolide compound in higher concentrations than a concurrently observed digoxin- like factor. Pretreatment of the animals with an antidigitalis antibody prevented the rapidly developing increases in cardiac contractility and more slowly developing natriuresis. A second study showed that voluntary hypoventilatory breathing in human subjects maintained by feedback from a respiratory gas monitor was also associated with increased in urinary excretion of the bufodienolide compound which persisted for 30 minutes following cessation of the breathing task. These studies have implications for understanding of the origins of hypertension and for development of new pharmacological interventions in cardiovascular disorders.