DEVELOPING PROBES OF CORTICO-STRIATAL CIRCUITRY

这是NIMH临床医生科学家发展奖的申请 （K-20），题为“开发皮质-纹状体回路的探针。“那 候选人的兴趣是神经精神疾病的神经科学 涉及基底神经节，特别是强迫症 (OCD)图雷特综合征（Tourette's disorder，TS） 皮质-纹状体回路 与强迫症和TS的病理生理学有关 虽然收敛 数据表明，单独的皮质-纹状体回路排列在一个 平行的，分离的方式，不同的皮质-纹状体 神经回路介导这两种疾病的症状， 对这些假设的经验检验是有限的。 候选 建议设计和实现特定的激活范例，以探测 离散并行皮质-纹状体回路，单独使用正电子 发射断层扫描（PET）研究成人受试者。 除了 激活研究以确定TS和OCD的介导神经解剖学， 受体表征技术将被用来探索可能的 纹状体神经化学异常 如此多面的 研究皮质-纹状体回路的方法有望产生 关于强迫症，TS和生理功能的重要信息 皮质-纹状体系统

This is a request for an NIMH Scientist Development Award for Clinicians (K-20) entitled "Developing Probes of Cortico-Striatal Circuitry." The candidate's interest is in the neuroscience of neuropsychiatric disorders involving the basal ganglia, particularly obsessive-compulsive disorder (OCD) and Tourette's disorder (TS). Cortico-striatal circuits have been implicated in the pathophysiology of OCD and TS. Although converging data suggest that separate cortico-striatal circuits are arranged in a parallel, segregated fashion, and that different cortico-striatal circuits mediate the symptoms of the two disorders, the capacity to empirically test such hypotheses has been limited. The candidate proposes to devise and implement specific activation paradigms to probe discrete parallel cortico-striatal circuits individually, using positron emission tomography (PET) to study adult subjects. In addition to activation studies to determine the mediating neuroanatomy of TS and OCD, receptor characterization techniques will be employed to explore possible neurochemical abnormalities within the striatum. Such a multifaceted approach to the study of cortico-striatal circuits promises to yield important information about OCD, TS, and the physiological functions of cortico-striatal systems.