NEUROBIOLOGY OF OPIOID DEPENDENCE

这一应用是为了研究兴奋性氨基酸输入和钙- 阿片类药物戒断过程中相关神经递质的释放。建议数 研究计划将检查：1)自发性阿片类药物戒断 临床阿片类药物戒毒研究，以及2)纳洛酮沉淀 反复挑战范式中的阿片类药物戒断。兴奋性氨基 酸对阿片类药物戒断的贡献将首先进行研究 右美沙芬，一种广泛使用的非阿片类镇咳药，可抑制 兴奋性氨基酸神经传递的临床前研究，并已 对阿片类药物戒断的治疗显示出试点疗效。基于Pre- 临床和先导性人体研究，拟议的研究将确定 中枢作用钙制剂尼莫地平的抗戒断作用 通道阻滞剂。

This application is to study excitatory amino acid inputs and calcium- linked neurotransmitter release during opiate withdrawal. The proposed program of research will examine: 1) spontaneous opiate withdrawal in clinical opiate detoxification studies, and 2) naloxone-precipitated opiate withdrawal in a repeated challenge paradigm. The excitatory amino acid contribution to opiate withdrawal will be studied initially with dextromethorphan, a widely used non-opioid antitussive which inhibits excitatory amino acid neurotransmission in pre-clinical studies, and has shown pilot efficacy for treatment of opiate withdrawal. Based on pre- clinical and pilot human studies, the proposed research will determine the anti-withdrawal efficacy of nimodipine, a centrally-acting calcium channel blocker.