CENTER FOR WOMENS HEALTH RESEARCH

这一P-30应用的目标是继续支持研究， 妇女一生的健康，特别是中年和 老年妇女的健康，通过完善和扩大核心 活动总的目标是继续和扩大我们的研究 任务通过两个研究核心，一个是推进，协调， 在不同的背景下巩固妇女健康知识， 社会文化环境（Sociocultural Environments） 是为了扩展我们对症状和 应激生理学和免疫系统功能（生物行为实验室 核心）。 今后五年的支助重点将放在 这些目标： L.通过生物行为实验室加强研究支持： a）发展免疫系统测量能力，包括 使用ELISA方法检测抗原或抗体;检测 使用标准铬释放的自然杀伤细胞活性测定 技术;使用细胞流鉴定表型亚群 流式细胞术;以及检测测量细胞因子浓度，例如 白细胞介素;和 B）继续提供与以下相关的类固醇和肽激素措施： HPA、HPO和交感肾上腺系统（i. e.雌激素，黄体酮， FSH、LH、儿茶酚胺、皮质醇、血清素、褪黑激素）;以及 c）提供关于实验室应激反应措施的咨询， 功能评估和睡眠测量; 2.支持中心调查员扩展和完善与以下方面有关的工作： 妇女健康的社会文化环境始于2005年， 多年的中心资金，并提高中心研究人员的能力， 以文化上胜任的方式研究不同的妇女群体，包括 发展社区伙伴关系，通过以下服务促进研究： 社会文化环境核心;以及 3.传播与妇女健康有关的科学，特别是 中年和老年妇女，各种观众，包括护理和其他 卫生研究人员、临床医生、妇女研究、决策者、 私营部门、通信媒体和公众， 尤其是女性。 中心的工作将通过四个核心来完成： 行政核心、研究发展和传播核心 生物行为实验室和社会文化环境核心。

The goal of this P-30 application is to continue to support research on women's health across the lifespan, and in particular, on midlife and older women's health, through the refinement and expansion of core activities. The overall objective is to continue and expand our research missions through two research cores, one to advance, coordinate, and consolidate knowledge of women's health in the context of diverse sociocultural environments (Sociocultural Environments Core) and the other is to extend our understanding of the relationship between symptoms and stress physiology and immune system function (Biobehavioral Laboratory Core). Special emphasis for the next five years of support will be placed on these objectives: l. Enhance the research support through the Biobehavioral Laboratories by: a) developing the capacity for immune system measurement, including detection of antigens or antibodies utilizing the ELISA method; detection of natural killer cell activity assay using standard chromium release techniques; identification of phenotype subsets using cellular flow cytometry; and detection of measure cytokine concentrations such as the interleukins; and b) continuing to provide steroid and peptide hormone measures related to the HPA, HPO and sympathoadrenal systems (i. e. estrogen, progesterone, FSH, LH, catecholamines, cortisol, serotonin, melatonin); and c) provide consultation on laboratory stress reactivity measures, gut function assessment, and sleep measures; 2. Support Center Investigators in extending and refining work related to sociocultural environments for women's health begun during the first five years of Center funding and enhance Center investigators' capacity to study diverse populations of women in culturally competent ways, including the development of community partnerships for research through services of the Sociocultural Environments Core; and 3. Disseminate the science related to women's health, particularly for midlife and older women, to various audiences, including nursing and other health researchers, clinicians, women's studies, policy-makers, the private sector, communications media, and to the general public, particularly women. The work of the Center will be accomplished through four cores: the Administrative Core, Research Development and Dissemination Core, the Biobehavioral Laboratory, and the Sociocultural Environments Core.