Proposal Title : NemeSys - Smart Multiphasic Nanoreactors Based On Tailored Foams for Direct H2O2 Synthesis

H2O2是一种关键的商品化学品。工业上采用间接工艺将溶解于有机溶剂中的蒽醌前体依次加氢氧化，然后液-液萃取回收H2O2，能量投入高，产生废弃物/CO2。一种可持续的替代方案依赖于由分子H2和O2直接合成H2O2，这种方法可以在使用终点产生H2O2，而下游操作很少。尽管如此，由于3个主要限制，这种理想的工艺还没有成为一种技术：(1)低H2O2选择性，(2)由于工艺安全而导致的生产率限制，(3)H2O2合成速度慢。这个ERC PoC项目旨在解决这些限制。它将通过在G-L界面自组装表面活性催化颗粒来实现颗粒稳定泡沫作为气-液-固（G-L- s）纳米反应器，促进催化中心附近的G-L混相。这将提高活性和H2O2选择性相比，散装催化系统低于爆炸极限。我们将优化已经在ERC Michelangelo中开发的颗粒，以在醇中产生泡沫，并将AuPd纳米颗粒作为催化相。我们将(i)制备基于含AuPd纳米合金的疏油有机硅的表面活性催化颗粒；（ii）在酒精中产生颗粒稳定泡沫，为直接合成H2O2和颗粒再利用提供高活性和选择性；（iii）设计一个实验室规模的G-L-S反应器原型，使用颗粒稳定泡沫实现至少0.6 vol% H2O2和H2O2合成速率bbb100 mol.kgcat-1.h-1；（iv）估算新反应堆原型的单位成本和二氧化碳足迹，与工业伙伴进行专利申请、技术转让和市场分析。通过在表面活性催化剂和工艺强化方面的创新，NemeSys将在过程工业中实现更高的可持续性和竞争力。

H2O2 is a key commodity chemical. It is industrially produced by an indirect process involving sequential hydrogenation-oxidation of an anthraquinone precursor dissolved in organic solvents followed by liquid-liquid extraction to recover H2O2, with high energy input and waste/CO2 generation. A sustainable alternative relies on direct H2O2 synthesis from molecular H2 and O2, which could produce H2O2 at the endpoint of use with few downstream operations. Nonetheless, this dream process has not emerged as a technology due to 3 main limitations: (1) low H2O2 selectivity, (2) productivity limitation due to process safety, and (3) slow rate of H2O2 synthesis. This ERC PoC project aims at bringing solution to these limitations. It will implement particle-stabilized foams as Gas-Liquid-Solid (G-L-S) nanoreactors by self-assembling surface-active catalytic particles at the G-L interface, promoting G-L miscibility near the catalytic centers. This will enhance the activity and H2O2 selectivity compared to bulk catalytic systems below the explosion limit. We will optimize particles already developed in the ERC Michelangelo to generate foams in alcohols, and incorporating AuPd nanoparticles as catalytic phase. We will (i) prepare surface-active catalytic particles based on oleophobic organosilicas incorporating AuPd nanoalloys; (ii) generate particle-stabilized foams in alcohols affording high activity and selectivity for direct H2O2 synthesis and particle reuse; (iii) engineer a lab-scale G-L-S reactor prototype using particle-stabilized foams to achieve at least 0.6 vol% H2O2 and a rate of H2O2 synthesis >100 mol.kgcat-1.h-1; and (iv) estimate the unit cost and CO2 footprint of the new reactor prototype, patenting, technology transfer and market analysis with industrial partners. Through innovation on both surface-active catalysts andprocess intensification, NemeSys will deliver a radical step change towards a higher sustainability and competitiveness in the process industry.