GENERAL CLINICAL RESEARCH CENTER

此申请适用于一家新的综合临床研究中心(GCRC) 将在康涅狄格大学健康中心(UCHC)建立。这 GCRC将发展为中心门诊设施，因为大多数 研究建议的一部分涉及门诊研究。用于住院研究 我们将在指定的内外科病房使用按日计算的床位，或者 关于像成人重症监护室这样的骨髓移植单元 护理病房和新生儿重症监护病房。该应用程序包含 23项个人研究提案，其中大部分涉及 基础科学家和临床研究人员之间的互动。的确有 特别强调分子生物学新方法的应用 以及人类遗传学对疾病发病机制的研究。这个 方案涵盖了广泛的临床疾病，包括骨骼和 结缔组织代谢、血液学和肿瘤学、神经科学和 精神病学、心肺疾病和免疫学疾病。此外 为了为这些项目提供设施和支持，广铁公司将 作为临床研究方面年轻研究人员的培训中心。 将提供新基础科学应用方面的专门培训 关于临床问题的技巧和临床通则 研究、生物统计分析和实验设计。 该大学和康涅狄格州已经做出了大量的， 继续致力于支持GCRC。州立和校内基金 已提供支持工作人员和资助试点项目，以发展这一点 求婚。香港中文大学中央行政部门及香港中文大学各学校院长 医学和牙科医学的目标是进一步发展 临床研究作为90年代S的主要目标，并证明了这一点 通过他们的持续支持。因此，我们相信，这一GCRC将 为促进临床研究提供创新和有效的手段。 我们建议探讨的具体研究问题以及 强调基础和临床科学家之间的互动， 以门诊为基础的方案和对新调查人员的培训应 在生物医学科学方面为我们地区和 这个国家。

This application is for a new General Clinical Research Center (GCRC) to be established at the University of Connecticut Health Center (UCHC). This GCRC will be developed as a central outpatient facility since the majority of research proposals involve outpatient studies. For inpatient studies we will use either per diem beds on a designated medical/surgical unit or on a unit such as the Bone Marrow Transplant Unit, the Adult Intensive Care Unit, and the Neonatal Intensive Care Unit. The application contains 23 individual research proposals, the majority of which involve interactions between basic scientists and clinical investigators. There is a special emphasis on the application of new methods of molecular biology and human genetics to the study of the pathogenesis of disease. The protocols cover a wide range of clinical disorders including bone and connective tissue metabolism, hematology and oncology, neurosciences and psychiatry, cardiopulmonary disease and immunologic disorders. In addition to providing facilities and support for these projects, the GCRC will serve as a center for training young investigators in clinical research. Specific training will be provided in the application of new basic science techniques to clinical problems and in the general principles of clinical research, biostatistical analysis and experimental design. The University and the State of Connecticut have made a substantial, ongoing commitment to support the GCRC. State and intramural funds have been provided to support the staff and fund pilot projects to develop this proposal. The UCHC central administration and the Deans of the Schools of Medicine and Dental Medicine have targeted the further development of clinical research as a major goal for the 90's and have demonstrated this through their continued support. Thus, we believe that this GCRC will provide an innovative and effective means of fostering clinical research. The specific research questions we propose to explore as well as the emphasis on interactions between basic and clinical scientists, on outpatient-based protocols and on the training of new investigators should lead to substantial advances in biomedical science for our region and for the nation.