EVALUATION OF IMMUNE THERAPIES FOR AIDS

目前，发育治疗学分会有几个动物模型 抗病毒药物评估合同，反机会主义 感染剂和基于免疫的疗法。这些资源是 可用于协助科学界，包括私人 在开发抗艾滋病毒/艾滋病疗法方面，该部门发挥了重要作用。这份合同 将提供一种实验模型，在该模型中，基于免疫的疗法可以 被评估其改善或恢复免疫功能的能力 受到病毒活动的危害。 该项目的目标是专注于目前尚未解决的问题 得到足够的关注，这代表着 基于免疫的治疗，即作用机制，光学调度， 确定与体内疗效相关的可量化参数， 基于免疫的和基于免疫的 抗逆转录病毒疗法和基于免疫的疗法的潜力 来上调病毒的表达。治疗方法的例子可以是 在模型中检查的包括：细胞因子、细胞因子拮抗剂、 抗体或细胞疗法，以缓解病毒为目标的药物- 诱导代谢紊乱，激素，非特异性免疫调节剂， 以及基于免疫的疗法与其他疗法的组合(用于 例如，抗逆转录病毒疗法)。

Presently, the Developmental Therapeutics Branch has several animal model contracts for the evaluation of antiviral agents, anti-opportunistic infection agents, and immune-based therapies. These resources are available to assist the scientific community, including the private sector, in the development of anti-HIV/AIDS therapies. This contract will provide an experimental model in which immune-based therapies can be evaluated for their ability to ameliorate or normalize immune function compromised by viral activity. The goal of the project is to focus on issues that currently do not receive adequate attention and that represent special problems for immune-based therapies, i.e., mechanism of action, optical scheduling, identification of quantifiable parameters related to in vivo efficacy, potential for positive or negative interaction between immune-based and anti-retroviral therapies, and the potential of immune-based therapies to upregulate virus expression. Examples of therapies that could be examined in the model include: cytokines, cytokine antagonists, antibody- or cell-based therapies, agents targeted to relieve virus- induced metabolic disturbances, hormones, non-specific immunomodulators, and combinations of immune-based therapies with other therapies (for example, anti-retroviral therapy).