IMMUNOGENICITY OF CURRENT MEASLES VACCINE IN HIV-INFECTED CHILDREN

活病毒疫苗一般禁忌在免疫功能低下 有复制这些病毒风险的个体。 麻疹本身 在感染艾滋病病毒的儿童中被证明是严重的。 虽然 到目前为止，研究表明，艾滋病毒感染儿童的疫苗接种是安全的， 麻疹疫苗免疫原性在这一群体中可能是次优的。 我们 一个实验室参与了一项抗体反应的评估， 比较一剂与两剂麻疹疫苗的随机II期研究 感染艾滋病毒的妇女所生的婴儿（6个月以下）。 这420名儿童将被随机分为两组 免疫接种时间表：6个月和15个月大接种麻疹疫苗， 15个月大时接种麻疹疫苗。 孩子们将被跟踪。 接种疫苗后9个月。 在420名患者中， 未感染和320例感染。 对于100名未感染的患者，70人将 随机分为两组，每组30例，每组1例。 为32 受感染的患者，一半将被随机接种2次疫苗， 其他人接种1次疫苗。 我们的实验室将负责 进行噬菌斑中和试验（PNT）和ELISA的血清从每个 A组第0、6、22、39、45、61、78和130周受试者， B组为45、61、78和130。 将ELISA反应性与PNT进行比较 滴度 研究入组将于今年秋季开始。

Live viral vaccines are generally contraindicated in immunocompromised individuals at risk for replicating these viruses. However, measles itself has proven to be severe in children with HIV infection. Although vaccination of HIV infected children has been safe in studies to date, the immunogenicity of measles vaccine in this group may be suboptimal. Our laboratory is involved in an evaluation of antibody responses in a randomized, phase II study comparing one versus two doses of measles vaccin in infants (less than 6 months old) who were born to HIV-infected women. The 420 children will be randomized to either one of two measles immunization schedules: measles vaccine at 6 and 15 months of age or measles vaccine at 15 months of age. The children will then be followed fo 9 months after their vaccination. Of the 420 patients, 100 will be uninfected and 320 infected. For the 100 patients uninfected, 70 would be randomized to have 2 vaccinations and 30 to have 1 vaccination. For the 32 infected patients, one half would be randomized to have 2 vaccinations and the rest to have 1 vaccination. Our laboratory will be responsible for conducting Plaque neutralization tests (PNT) and ELISAs of sera from each subject at 0, 6, 22, 39, 45, 61, 78, and 130 weeks for Group A and 0, 39, 45, 61, 78, and 130 for Group B. ELISA reactivity will be compared to PNT titers. The study enrollment will begin in the fall of this year.