NEW ORLEANS COOP AGREEMENT FOR AIDS CMTY OUTREACH/INTERV

这项申请建议进行一项为期五年的研究，以监测艾滋病毒 风险行为和评估强化干预的有效性 抗击艾滋病毒感染在纽约目标人群中的传播 奥尔良。目标人群包括静脉注射吸毒者。 (静脉吸毒者)，通过性交易换取毒品或金钱的妓女，可卡因 吸毒者、静脉注射吸毒者的性伴侣、妓女和吸毒者。 这项拟议研究的所有参与者将从十个大的 新奥尔良的公共住房项目。 这项研究将采用准实验设计，其中10个 住房项目将在重要特征上进行匹配 成对的。每对匹配的项目中的一个将被随机分配 实验(即“强化”)或对照(即“标准”) 干预条件。实验性干预，它建立在 根据我们最近对静脉注射吸毒者社区外展的研究经验，Will 包括(A)疾控中心批准的“以知识为基础”的干预方案 在我们的外展办公室由训练有素的人员提供，(B)额外 我们办公室提供的艾滋病毒预防信息，以及(C)风险 减少技能--在六个“现场”课程中提供培训 这将在参与者自己的地盘上进行 12周内的住房项目。居住在 随机分配到控制条件的五个住房项目将 只在我们的外展办公室接受标准的疾控中心干预。 30个月后，加强干预措施将扩大到 从住房项目中抽出的控制状况。 成果衡量标准将主要包括艾滋病毒风险指标。 由NIDA的AIA和AFA衡量的行为。此外，我们还将评估 其他潜在的重要结果，如心理调整， 接受药物治疗的准备情况、药物治疗的次数和时间 事件等。过程措施将包括评估 处理实施和跨条件污染。多个- 将使用变量分析和表格分析来评估初始 住房项目对参与者的可比性， 测量AIA和AFA对干预的反应性，以及 评估强化干预措施的有效性。评估 会将加强干预措施的风险程度视为 以及基线特征之间的显著差异 来自两个条件的参与者在每个住房项目中配对。

This application proposes to conduct a five-year study to monitor HIV risk behavior and evaluate the effectiveness of an enhanced intervention to combat the spread of HIV infection among targeted populations in New Orleans. The targeted populations include intravenous drug users (IVDUs), prostitutes who trade sex for drugs or money, crack cocaine users, and the sexual partners of IVDUs, prostitutes, and crack users. All participants in the proposed study will be drawn from ten large public housing projects in New Orleans. The study will employ a quasi-experimental design in which the ten housing projects will be matched on important characteristics into pairs. One of each pair of matched projects will be randomly assigned to an experimental (i.e., "enhanced") or control (i.e., "standard") intervention condition. The experimental intervention, which builds upon our recent research experience in community outreach to IVDUs, will consist of (a) a CDC approved "knowledge-based" intervention protocol provided at our outreach office by trained personnel, (b) additional information on HIV prevention provided at our office, and (c) risk reduction skills-building training provided in six "onsite" sessions that will be conducted with participants on their own turf in the housing projects over a 12-week period. Participants who reside in the five housing projects randomly assigned to the control condition will receive the standard CDC intervention only at our outreach office. After 30 months, the enhanced intervention will be extended to persons drawn from the housing projects in the control condition. Outcome measures will consist primarily of indicators of HIV risk behavior as measured by NIDA's AIA and AFA. In addition, we will assess other potentially important outcomes, such as psychological adjustment, readiness for drug treatment, number and length of drug treatment episodes, etc. Process measures will include assessment of level of treatment implementation and across-condition contamination. Multi- variate and tabular analyses will be used to assess the initial comparability of participants from the pairs of housing projects, measure the reactivity of the AIA and AFA with the intervention, and evaluate the effectiveness of the enhanced intervention. The evaluation will consider the extent of exposure to the enhanced intervention as well as significant differences between the baseline characteristics of participants from the two conditions in each housing project pair.