MACULAR PHOTOCOAGULATION STUDY

老年性黄斑变性是老年人严重视力丧失的主要原因。 美国60岁以上的人。 眼组织胞浆菌病可能是第二个 导致视力下降的主要原因是生活在流行病中的中青年人 区 在这两种疾病中，视力丧失最常由并发症引起。 黄斑部脉络膜新生血管形成 黄斑光凝研究（MPS）是一项多中心、随机临床研究， 试验旨在回答这个问题：是使用氩激光 光凝术对中心凹外脉络膜新生血管闭塞的价值 在预防视力丧失方面的作用 黄斑光凝研究包括 两个子研究：老年性黄斑变性研究和眼科研究。 组织胞浆菌病研究。 符合资格标准并同意参加的患者将 将一只眼睛随机分配到氩激光光凝或“不治疗”组。" 患者将每6个月随访一次，随访时间长达5年。 视觉 将使用敏锐度来评估治疗与不治疗的价值。 所有数据将在中央协调中心收集和分析， 所有眼底照片和荧光素血管造影片将在 眼底照相阅读中心。 数据监测委员会将评估 委员会每年多次收集数据，并向执行委员会报告其调查结果。 任何重大发现将及时报告给参与患者， 转诊眼科医生和眼科社区。 每例患者对侧眼的临床和摄影数据将用于 评估与脉络膜发展相关的风险因素 新血管形成，并进一步了解这些疾病的自然史， 紊乱

Senile macular degeneration is the leading cause of severe visual loss in the United States in people beyond age 60. Ocular histoplasmosis may be the second leading cause of visual loss in young and middle-aged living in the endemic area. In both disorders, visual loss most often results from the complications of choroidal neovascularization in the macula. The Macular Photocoagulation Study (MPS) is a multicenter, randomized clinical trial designed to answer the question: Is the use of argon laser photocoagulation to obliterate extrafoveal choroidal neovascularization of value in preventing visual acuity loss? The Macular Photocoagulation Study consists of two substudies: the Senile Macular Degeneration Study and the Ocular Histoplasmosis Study. Patients who meet the eligibility criteria and who agree to participate will have one eye randomized to argon laser photocoagulation or to "no treatment." Patients will be followed at six-month intervals for up to five years. Visual acuity will be used to assess the value of treatment versus no treatment. All data will be collected and analyzed at a central Coordinating Center, and all fundus photographs and fluorescein angiograms will be interpreted at the Fundus Photograph Reading Center. A Data Monitoring Committee will evaluate data several times per year and report its findings to the Executive Committee. Any significant findings will be reported promptly to participating patients, to referring ophthalmologists, and to the ophthalmic community. Clinical and photographic data of the fellow eye of each patient will be used to evaluate risk factors associated with the development of choroidal neovascularization and to further our knowledge of the natural history of these disorders.