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MONOCLONAL ANTIBODY THERAPY OF GI CANCERS

MONOCLONAL ANTIBODY THERAPY OF GI CANCERS
胃肠道癌的单克隆抗体治疗
批准号:
2097925
负责人:
KENNETH A FOON
金额:
$35.21万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
1991
资助国家:
美国
项目状态:
已结题
起止时间:
1991-09-30 至 1995-08-31

项目摘要

项目成果

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中文摘要
翻译
该计划项目赠款的重点是应用程序 用于治疗胃肠道(GI)疾病的单克隆抗体(mAb) 癌 临床前研究将重点关注抗独特型mAb 疫苗。 个人研究的具体目标 项目如下:1.抗独特型的产生 胃肠道癌的抗体2.测定抗- 独特型单克隆抗体,确定DNA和蛋白质序列, 决定环路、序列和独特位的计算机模型 合成肽,作为临床试验的第一步。 3.使用抗独特型mAb(抗- 8019)。
英文摘要
This Program Project Grant is focused on the applications of monoclonal antibodies (mAbs) for therapy of gastrointestinal (GI) cancer. Preclinical studies will focus on anti-idiotype mAb vaccines. The specific objectives of the individual research projects are the following: 1. Generation of anti-idiotype antibodies for GI carcinoma. 2. Determining the avidities of anti- idiotype mAbs, determine the DNA and protein sequences, generate computer models for idiotope determining loops, sequence and synthesize the peptides, as the first step towards clinical trials. 3. Clinical trial for GI cancer with an anti-idiotype mAb (anti- 8019).
期刊论文(3)
专著(0)
科研奖励(0)
会议论文
Preclinical evaluation in nonhuman primates of an anti-idiotypic antibody that mimicks the carcinoembryonic antigen.
在非人灵长类动物中模拟癌胚抗原的抗独特型抗体的临床前评估。
DOI: 10.1097/00002371-199508000-00003
发表时间: 1995
期刊: Journal of immunotherapy with emphasis on tumor immunology : official journal of the Society for Biological Therapy.
影响因子: --
作者: [Chakraborty,M, Foon,KA, Kohler,H, Bhattacharya-Chatterjee,M]
通讯作者: Bhattacharya-Chatterjee,M
Induction of human breast cancer-specific antibody responses in cynomolgus monkeys by a murine monoclonal anti-idiotype antibody.
通过鼠单克隆抗独特型抗体在食蟹猴中诱导人乳腺癌特异性抗体反应。
DOI: --
发表时间: 1995
期刊: Cancer research.
影响因子: --
作者: [Chakraborty,M, Mukerjee,S, Foon,KA, Kohler,H, Ceriani,RL, Bhattacharya-Chatterjee,M]
通讯作者: Bhattacharya-Chatterjee,M
CORE--PROTOCOL SPECIFIC RESEARCH
ANTIIDIOTYPE VACCINE WITH IL2 FOR ADVANCED MELANOMA
  • 批准号:
    2717588
  • 项目类别:
  • 资助金额:
    $4.14万
  • 财政年份:
    1998
  • 负责人:
    KENNETH A FOON
  • 依托单位:
SOUTHWEST ONCOLOGY GROUP
  • 批准号:
    2856486
  • 项目类别:
  • 资助金额:
    $3.74万
  • 财政年份:
    1998
  • 负责人:
    KENNETH A FOON
  • 依托单位:
SOUTHWEST ONCOLOGY GROUP
  • 批准号:
    6137642
  • 项目类别:
  • 资助金额:
    $4.06万
  • 财政年份:
    1998
  • 负责人:
    KENNETH A FOON
  • 依托单位:
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