ASSESSMENT OF PSYCHOLOGICAL ISSUES RELATED TO SUBSTANCE ABUSE TREATMENT

临床试验受试者的心理测评 已经成为该部门研究兴趣的重要组成部分。几个 进行了研究：寻求治疗的吸毒者的比较 和不寻求治疗；对人格障碍的评估 寻求研究治疗的可卡因依赖者；以及一项调查 治疗的动机。 研究人员和治疗提供者面临的一个重要问题是 妇女和少数群体在可卡因滥用中的报告和代表性 药物治疗临床试验。61年的社会人口代表性 关于可卡因滥用的门诊药物治疗的报告，发表在 比较了1983年和1993年间的英文期刊《参考文献》 1990年全国可卡因频繁使用情况的流行病学分析 药物滥用家庭调查(NIDA-HS)。调查结果显示， 重要的社会人口学数据通常不会在论文中报道，而且 提出研究报告的质量、结果的概括性、 社会公平和某些可卡因滥用群体的可及性 药物治疗研究。 在程序性研究中确定临床上改善的结果变量 试验：尿液定量分析可卡因代谢物的有效性 和肌酐校正技术以及它们之间的关系 数据和自我报告的药物使用情况是通过在一项 应急管理行为治疗的临床试验(N=37) 干预。制定规则是为了区分不同的场合 在尿液阳性定性测试中的新用途和带入。 初步分析表明：尿液定性和定量检测 显示比自我报告显示的更高的吸毒率； 定量测试提供了一种区分疾病发生率的方法 来自残留结转的新药物使用；通过 定量测试可能有助于调和不同比率之间的差异 通过尿液定性筛查和自我报告显示药物使用情况。 汗片已被证明在测量可卡因和鸦片类药物方面是有效的 在受控的临床实验室环境中使用，但以前没有 在更现实的环境下进行了测试，如我们的治疗诊所。 收集汗液作为监测药物使用的一种方法可能更 比尿检准确可靠的时间更长 当前使用的方法。评估项目有效性的目的 收集汗液作为监测药物使用的另一种方法。 结果将与尿样监测的药物使用情况进行比较 每周收集三次。

The psychological assessment of subjects participating in clinical trials has become an important part of the section's research interest. Several studies were conducted: a comparison of drug abusers seeking treatment and not seeking treatment; an evaluation of personality disorders in cocaine dependent individuals seeking research treatment; and a survey of motivation for treatment. An important issue facing researchers and treatment providers is the reporting and representation of women and minorities in cocaine abuse pharmacotherapy clinical trials. Sociodemographic representation in 61 reports of outpatient pharmacotherapy for cocaine abuse, published in refereed, English language journals, between 1983 and 1993 was compared to the epidemiology of frequent cocaine use in the 1990 NIDA National Household Survey of Drug Abuse (NIDA-HS). The findings showed that important sociodemographic data is often not reported in papers, and raise issues of quality of research reports, generalizability of results, social equity, and accessibility for certain groups in cocaine abuse pharmacotherapy research. In procedural studies to identify improved outcome variable in clinical trials, the usefulness of quantitative urinalysis for cocaine metabolite and creatinine correction techniques and the relationship between these data and self-reported drug use were assessed with data collected in a clinical trial (N = 37) of a contingency management behavioral treatment intervention. Rules were developed to differentiate between occasions of new use and carry-over in positive qualitative urine tests. Preliminary analyses suggest: qualitative and quantitative urine testing show greater rates of drug use than that shown by self report; quantitative testing provides a means of differentiating incidences of new drug use from residual carry-over; the identification of new use with quantitative testing may help to reconcile differences between rates of drug use indicated by qualitative urine screens and self-report. Sweat patches have been proven effective in measuring cocaine and opiate use in controlled clinical laboratory settings but have not previously been tested under more realistic settings such as our treatment clinic. Collection of sweat as a method of monitoring drug use may be more accurate and reliable over a longer period of time than the urine testing method currently used. The purpose to evaluate the effectiveness of collecting sweat as an alternative method of monitoring drug use. Results will be compared to drug use as monitored by urine samples collected three times a week.