VASCULAR RELATIONS OF BLOOD CELLS AND PROTEINS

本研究旨在探讨正常人血液流变学和血流动力学的变化， 和病理模型是一个跨学科的合作努力， 表征血细胞的生化和物理特性， 膜和粘合剂分子，因为这些性质对 红细胞和白细胞的成熟;有助于 微循环;由于它们与微血管炎症有关， 反应和闭塞现象。 这些努力集中在生理上， 细胞成熟和活化的过程，微血管中的流动 （包括细胞粘附到内皮和闭塞），和运输 氧气，并联合收割机的实验方法，以临床问题， 重要性与工程的分析和理论贡献 科学家和生物学家。 用于研究的模型障碍包括镰状 细胞疾病、遗传性球形红细胞增多症、糖尿病、白血病和 血管闭塞性疾病 建议的项目包括：（1） 粘附分子与血细胞相互作用的研究 和内皮细胞表面，在流动条件下， （2）成熟血细胞的力学性质研究 以及它们如何影响血液微循环;（3）对照检查 微血管血流的机制，包括对 （4）开发和利用现实的 微血管血流的数学模型;（5）模型的扩展 和微循环流动研究的理论研究， 用于解释观察到的细胞相互作用的流体动力学基础。 三 核心单位提供行政职能，流式细胞术实验室 服务和全面的图像分析系统。

The objective of this study of blood rheology and hemodynamics in normal and pathological models is a collaborative interdisciplinary effort to characterize the biochemical and physical properties of blood cells, their membranes and adhesive molecules, as these properties have significance to maturation of erythrocytes and leukocytes; contribute to flow behavior in the microcirculation; and as they pertain to microvascular inflammatory response and occlusive phenomena. The efforts focus on the physiological processes of cell maturation and activation, flow in the microvasculature (including cell adhesion to endothelium, and occlusion), and transport of oxygen, and combine the experimental approaches to issues of clinical importance with analytical and theoretical contributions of engineering scientists and biophysicists. Model disorders for study include sickle cell disease, hereditary spherocytosis, diabetes, leukemias and vaso-occlusive disorders. The proposed projects include: (1) Investigations of the interactions of adhesion molecules with blood cell and endothelial cell surfaces, under flow conditions, and the adhesion processes; (2) Studies of the mechanical properties of maturing blood cells and how they affect blood microcirculation; (3) Examination of control mechanisms of microvascular blood flow, including responses to the presence of altered blood cells; (4) Development and utilization of realistic mathematical models of microvascular blood flow; and (5) Extension of model and theoretical studies of studies of microcirculatory flow to provide hydrodynamic bases for interpreting observed cellular interactions. Three core units provide administrative functions, a flow cytometry laboratory service, and a comprehensive image analysis system.