NEUROPHYSIOLOGY & NEUROPSYCHOLOGY IN MENTAL RETARDATION

这是一项计划项目拨款的续订申请，旨在 在完整和实验中阐明发育的重要方面 受损的哺乳动物基底节和大脑皮层。这项研究如下 两个主题：第一个是神经元通讯的发展和 大脑皮质和基底节的条件性学习。第二个主题 关注胎儿期及早期对神经元通讯的影响 出生后脑损伤。这笔赠款的五个组成部分中的每一个 是针对这些主题中的至少一个主题及其基础的 假设。 这项研究涉及基础电生理、药理学和 体外(脑片)和体外培养的发育中神经元的形态研究 活着。重要的行为研究将评估术后功能的恢复 产前皮质损伤，并将检查细胞基础 条件性学习。将要进行的许多实验都是经过设计的 作为发育性脑残疾的模型，包括智力障碍 智力迟缓。一些基本的方法已经被应用于 未成熟人脑组织在儿童癫痫临床治疗中的应用 (单独出资)。最后，这项计划项目赠款作为一个 中国研究生和博士后的重要培训工具 智障研究中心。

This is a renewal application for a program project grant designed to elucidate important aspects of development in intact and experimentally damaged mammalian basal ganglia and cerebral cortex. The research follows two main themes: The first is development of neuronal communication and conditioned learning in the cortex and basal ganglia. The second theme concerns the effects on neuronal communication of prenatal and early postnatal brain damage. Each of the five component projects of this grant is addressed to at least one of these themes and to their underlying hypotheses. The research involves basic electrophysiological, pharmacological, and morphological studies of developing neurons in vitro (brain slices) and in vivo. Important behavioral studies will assess recovery of function after prenatal cortical lesions, and will examine the cellular bases of conditioned learning. Many of the experiments to be undertaken are designed as models for developmental brain disabilities, including mental retardation. Some of the basic approaches are already being applied to immature human brain tissue in a clinical program on pediatric epilepsy (separately funded). Finally, this program project grant acts as an important training vehicle for graduate and postdoctoral students in the Mental Retardation Research Center.