课题基金 / 基金详情

MONITORING PARKINSONISM IN PATIENTS WITH COMPLEX PATTERNS OF RESPONSE

MONITORING PARKINSONISM IN PATIENTS WITH COMPLEX PATTERNS OF RESPONSE
监测具有复杂反应模式的帕金森病患者
批准号：
3786542
负责人：
STEPHEN T GANCHER
金额：
$0.0万
依托单位：
OREGON HEALTH & SCIENCE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/3786542
关键词：
Parkinson's disease antiparkinson drugs dihydroxyphenylalanine human subject human therapy evaluation nervous system disorder chemotherapy neurologic manifestations patient monitoring device pharmacokinetics

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相关文献

中文摘要
翻译
长期使用左旋多巴治疗的帕金森病患者可能会发生 神经症状的复杂波动。我们将监测患者的 清醒时每小时的神经体征和血浆左旋多巴 为期两天：1.确定是否建立了震级和模式 波动的症状和体征会导致更好的控制， 具有成本效益的服务。2.探索不寻常的反应模式 药代动力学和药效学性质的其他线索 左旋多巴。
英文摘要
Parkinsonian patients treated chronically with levodopa may develop complex fluctuations of neurological symptoms. We will monitor patients' neurological signs and plasma levodopa hourly throughout the waking hours for two days to: 1. Determine if establishing the magnitude and pattern of fluctuating symptoms and signs leads to improved control and would be a cost effective service. 2. Explore unusual patterns of response for other clues to the pharmacokinetic and pharmacodynamic properties of levodopa.
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会议论文
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