Cytokine and macrophage determinants of pulmonary inflammation during tuberculosis

结核病感染了世界33%的人口，每年造成200多万人死亡。结核病引起破坏性的肺部病理，迫切需要治疗感染和中度炎症的新疗法。肿瘤坏死因子对结核病免疫至关重要，可调节炎症。这笔拨款将确定可溶性和膜结合TNF如何调节结核病病理的细胞和细胞因子控制，并可能导致新的治疗方法来限制结核病和其他炎症性疾病的炎症。

Tuberculosis (TB) infects 33% of the world, causing over 2 million deaths per year. TB disease causes damaging lung pathology and new therapies to treat the infection and moderate inflammation are urgently required. TNF is essential for immunity to TB, acting to modulate inflammation. This grant will determine how soluble and membrane- bound TNF regulate the cellular and cytokine control of TB pathology and may lead to new therapies to limit inflammation in TB and other inflammatory diseases.