HPV--BIOLOGY, CLINICAL SIGNIFICANCE AND EPIDEMIOLOGY

该计划项目是多学科研究的延续， 人乳头瘤病毒在肛门生殖器癌病因学中的作用。 的 个别项目涉及这些疾病的流行病学， 在发病机制和免疫机制方面的反应， 表达乳头瘤病毒基因的细胞生物学。 四个项目具有 建议：第一个项目（0001）解决免疫问题 对乳头瘤病毒感染的反应以及免疫调节在 进展为癌症。 第二个项目（0002）审查了 细胞对乳头瘤病毒基因应答的增殖特性 表达，并将决定机制，通过辅因子 导致恶性进展。 第三个项目（0004） 继续进行病例对照研究，调查HPV在 肛门生殖器癌的发展。 第四个项目（0006）涉及一个 评估先前确定为HPV阳性的病例的预后， 细胞学和分子杂交。 这些项目得到四个 核心将提供分子生物学，组织学和细胞学 支持以及生物统计分析和行政监督。

This program project is a continuation of multidisciplinary studies of the role of human papillomaviruses in the etiology of anogenital cancers. The individual projects address the epidemiology of these diseases, the host response in terms of pathogenesis and mechanisms of immunity and the biology of cells expressing papillomavirus genes. Four projects are proposed: The first project (0001) addresses the questions of immune response to papillomavirus infection and the role of immune modulation in progression to cancer. The second project (0002) examines the characteristics of cells proliferating in response to papillomavirus gene expression and will determine the mechanisms through which cofactors contribute to progression to malignancy. The third project (0004) continues case-control studies investigating the role of HPV in the development of anogenital cancers. The fourth project (0006) deals with an evaluation of prognosis of cases previously identified as HPV positive by cytology and molecular hybridization. The projects are supported by four cores which will provide molecular biological, histological and cytological support as well as biostatistical analysis and administrative oversight.