PEDIATRIC ONCOLOGY GROUP STUDIES

拟议研究的总体目标是继续努力， 为患有各种癌症的儿童确定最佳护理。 的 研究机制涉及儿科研究者的参与， 鲍曼格雷医学院在多学科合作 儿科肿瘤学组的临床肿瘤学方案以及 继续与北卡罗来纳州和南卡罗来纳州的其他中心合作。 拟议的研究补助金将允许继续参与 鲍曼格雷医学院作为儿科的正式成员 肿瘤学组，并将为我们的附属机构提供支持， 格林维尔，南卡罗来纳州。 作为我们不断扩张的自然产物， 计划和活动，这笔赠款将提供直接独立的 鲍曼·格雷医学院（Bowman Gray School of Medicine） 杜克大学的附属机构）。 我们在过去几年的成就已在 赠款提案。 我们在这五年期间的机构目标 赠款包括：（1）继续我们的记录增加应计费用和我们的 对POG的卓越临床贡献，包括我们100%的记录 患者可评估性和方案依从性;（2）扩大我们的 机构参与POG白血病的设计和开发 研究;（3）进一步发展我们对大脑的兴趣 肿瘤和我们的神经肿瘤学诊所，导致越来越多的患者 根据脑肿瘤方案和POG中的研究者角色入组 脑肿瘤委员会;（4）继续大力参与POG 霍奇金病的活动;（5）晚期效应的发展增加 研究和积极参与POG后期效应委员会;（6） 我们在POG细胞遗传学委员会中的作用显著扩大， 第二个POG细胞遗传学参考实验室的发展， 鲍曼·格雷;（7）继续对行政管理做出重大贡献 POG的各个方面，正如我们目前在 执行和机构业绩审查委员会。 最后，我们计划继续与我们的 附属机构在格林维尔，SC的目标是确保最佳的 为我们转诊地区的所有癌症儿童提供临床护理。

The overall goal of the proposed research is to continue to work towards determining the optimum care for children with all types of cancer. The research mechanism involves participation by pediatric investigators at the Bowman Gray School of Medicine in collaborative multidisciplinary clinical oncology protocols of the Pediatric Oncology Group as well as continued collaboration with other centers in North and South Carolina. The proposed research grant will allow for the continued participation of the Bowman Gray School of Medicine as a full member of the Pediatric Oncology Group and will provide support for our affiliate institution in Greenville, South Carolina. As a natural outgrowth of our expanding program and activities, this grant will provide for direct independent funding of the Bowman Gray School of Medicine (formerly funded as an affiliate of Duke University). Our accomplishments in the past years are described in detail in the grant proposal. Our institutional goals for the five year period of this grant include: (1) continuing our record of increasing accrual and our excellent clinical contribution to the POG, including our record of 100% patient evaluability and protocol compliance; (2) expanding our institutional involvement in the design and development of POG leukemia studies; (3) further institutional development of our interest in brain tumors and our neuro-oncology clinic, leading to increasing patient enrollment on brain tumor protocols and to investigator roles in the POG Brain Tumor Committee; (4) continuation of our strong involvement in POG Hodgkin's disease activities; (5) increasing development of late effects studies and active participation with the POG Late Effects Committee; (6) significant expansion of our role in the POG Cytogenetics Committee and the development of a second POG Cytogenetics Reference Laboratory at Bowman Gray; (7) continued major contributions to the administrative aspects of the POG, as presently exemplified by our roles on the Executive and Institutional Performance Review Committees. Finally, we plan to continue our very close working relationship with our affiliate institution in Greenville, SC with the goal of assuring optimal clinical care for all children with cancer in our referral area.